Levels of awakening salivary CgA in response to stress in healthy subjects

To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests. The study cohort comprised 40 healthy male university students (age range 19-22...

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Bibliographic Details
Published in:Environmental health and preventive medicine 2011-05, Vol.16 (3), p.155-157
Main Authors: REI DEN, TODA, Masahiro, OHIRA, Masako, MORIMOTO, Kanehisa
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Biomarkers - analysis
Body fluids
Chromogranin A - analysis
Chromogranin A - physiology
Depression
Depressive Disorder - physiopathology
Environmental health
Humans
Japan
Male
Medical sciences
Mental depression
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Regular
Saliva - chemistry
Sleep
Stress
Stress, Psychological - diagnosis
Stress, Psychological - etiology
Stress, Psychological - physiopathology
Time Factors
Young Adult
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Summary:To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests. The study cohort comprised 40 healthy male university students (age range 19-22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening). The salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low (n = 26) and high (n = 14), respectively, on the "severe depression" subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant (p < 0.05). Our findings indicate that depression may influence secretions of salivary CgA via chronic stress-related attenuation of the sympathetic-adrenomedullary system activity.
ISSN:1342-078X
1347-4715
DOI:10.1007/s12199-010-0179-5