RADSeq: next-generation population genetics

Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA seque...

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Bibliographic Details
Published in:Briefings in functional genomics 2010-12, Vol.9 (5-6), p.416-423
Main Authors: Davey, John W, Davey, John L, Blaxter, Mark L, Blaxter, Mark W
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Genetic Variation
Genetics, Population
Genome
Humans
Phylogeny
Polymorphism, Single Nucleotide
Restriction Mapping
Sequence Analysis, DNA - methods
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Summary:Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA sequencing, a method that samples at reduced complexity across target genomes, promises to deliver high resolution population genomic data-thousands of sequenced markers across many individuals-for any organism at reasonable costs. It has found application in wild populations and non-traditional study species, and promises to become an important technology for ecological population genomics.
ISSN:2041-2649
2041-2657
DOI:10.1093/bfgp/elq031