The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

In 1967, it was reported that experimental inoculation of serum from a surgeon (G.B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family Flaviviridae, named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with...

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Bibliographic Details
Published in:Journal of general virology 2011-02, Vol.92 (Pt 2), p.233-246
Main Authors: STAPLETON, Jack T, FOUNG, Steven, MUERHOFF, A. Scott, BUKH, Jens, SIMMONDS, Peter
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Flaviviridae
Flaviviridae - classification
Flaviviridae - genetics
Flaviviridae - physiology
Flaviviridae Infections - immunology
Flaviviridae Infections - virology
Fundamental and applied biological sciences. Psychology
Hepatitis C virus
Hepatitis G virus
Hepatitis, Viral, Animal - immunology
Hepatitis, Viral, Animal - virology
Hepatitis, Viral, Human - immunology
Hepatitis, Viral, Human - virology
Humans
Microbiology
Miscellaneous
Monkey Diseases - immunology
Monkey Diseases - virology
Phylogeny
Platyrrhini
Review
Terminology as Topic
Virology
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Summary:In 1967, it was reported that experimental inoculation of serum from a surgeon (G.B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family Flaviviridae, named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with the 11th GB passage. Neither virus infects humans, and a number of GBV-A variants were identified in wild New World monkeys that were captured. Subsequently, a related human virus was identified [named GBV-C or hepatitis G virus (HGV)], and recently a more distantly related virus (named GBV-D) was discovered in bats. Only GBV-B, a second species within the genus Hepacivirus (type species hepatitis C virus), has been shown to cause hepatitis; it causes acute hepatitis in experimentally infected tamarins. The other GB viruses have however not been assigned to a genus within the family Flaviviridae. Based on phylogenetic relationships, genome organization and pathogenic features of the GB viruses, we propose to classify GBV-A-like viruses, GBV-C and GBV-D as members of a fourth genus in the family Flaviviridae, named Pegivirus (pe, persistent; g, GB or G). We also propose renaming 'GB' viruses within the tentative genus Pegivirus to reflect their host origin.
ISSN:0022-1317
1465-2099
1465-2099
DOI:10.1099/vir.0.027490-0