Anxiety and self-perceived health status in Parkinson’s disease

Abstract Both anxiety and depression are associated with lower self-perceived health status (HS) in persons with Parkinson’s disease (PD). Given the high co-morbidity with depression and other non-motor symptoms, it is unclear whether anxiety disorders, in general, versus specific anxiety subtypes h...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2011-05, Vol.17 (4), p.249-254
Main Authors: Pontone, Gregory M, Williams, James R, Anderson, Karen E, Chase, Gary, Goldstein, Susanne R, Grill, Stephen, Hirsch, Elaina S, Lehmann, Susan, Little, John T, Margolis, Russell L, Rabins, Peter V, Weiss, Howard D, Marsh, Laura
Format: Article
Language:English
Subjects:
Anxiety
Anxiety - epidemiology
Comorbidity
Depressive Disorder - epidemiology
Fluctuations
Health Status
Humans
Neurology
Non-motor symptoms
Parkinson Disease - epidemiology
Parkinson Disease - psychology
Parkinson’s disease
Psychiatric disorders
Quality of life
Surveys and Questionnaires
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Summary:Abstract Both anxiety and depression are associated with lower self-perceived health status (HS) in persons with Parkinson’s disease (PD). Given the high co-morbidity with depression and other non-motor symptoms, it is unclear whether anxiety disorders, in general, versus specific anxiety subtypes have an independent effect on HS in PD. To examine this question, comprehensive assessments of motor and non-motor symptoms from 249 subjects with idiopathic PD followed in three community-based movement disorders neurology practices were analyzed. HS was measured using the 8-item PD Questionnaire (PDQ-8). Psychiatric diagnoses were established by consensus using a panel of six psychiatrists with expertise in geriatric psychiatry and movement disorders. Stepwise multiple regression analyses were used, with the PDQ-8 score as the dependent variable, to identify independent predictors of HS among motor, psychiatric, and other non-motor variables. Among the anxiety disorders, only anxiety associated with motor fluctuations was an independent predictor of HS after accounting for co-morbid depression and other clinical features. In addition, depressive disorders were also an independent predictor of lower HS. Prevention or treatment of state-dependent anxiety may improve HS in persons with PD.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2011.01.005