Lantana montevidensis Briq improves the aminoglycoside activity against multiresistant Escherichia coli and Staphylococcus aureus

Objective : In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq. Materials and Methods : The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresista...

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Bibliographic Details
Published in:Indian journal of pharmacology 2011-03, Vol.43 (2), p.180-182
Main Authors: Sousa, Erlanio O, Almeida, Thiago S, Rodrigues, Fabíola F.G, Campos, Adriana R, Lima, Sidney G, Costa, José G.M
Format: Article
Language:English
Subjects:
Aminoglycosides
Aminoglycosides, antibacterial and modulatory activities, Lantana montevidensis Briq
Antibacterial agents
Care and treatment
Control
Escherichia coli
Escherichia coli infections
Health aspects
Materia medica, Vegetable
Medicine, Botanic
Medicine, Herbal
Plant extracts
Properties
Staphylococcus aureus
Staphylococcus aureus infections
Verbena
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Summary:Objective : In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq. Materials and Methods : The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant strains of Escherichia coli (Ec 27) and Staphylococcus aureus (Sa 358) were used. Results : The results show the inhibitory activity of LELm against E. coli (minimal inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128 μg/mL). The synergistic effect of the extracts and aminoglycosides was verified too. The maximum effects were obtained with RELm with gentamicin against E. coli with MIC reduction (312 to 2 μL). Conclusion : The data from this study are indicative of the activity antibacterial of extracts of L. montevidensis and its potential in modifying the resistance of aminoglycosides.
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.77359