Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway Promote Consecutive Multienzyme Reactions with a Synergistic Effect

Synergistic gathering: Biochemical studies reveal a highly efficient strategy in biosynthesis to promote consecutive multienzyme reactions. In the curacin A pathway, catalytic efficiency of a multi‐step modification process and one‐step translocation is significantly enhanced by tandem organization...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2011-03, Vol.50 (12), p.2795-2798
Main Authors: Gu, Liangcai, Eisman, Eli B, Dutta, Somnath, Franzmann, Titus M, Walter, Stefan, Gerwick, William H, Skiniotis, Georgios, Sherman, David H
Format: Article
Language:English
Subjects:
acyl carrier protein
Acyl Carrier Protein - genetics
Acyl Carrier Protein - metabolism
biosynthesis
Biosynthetic Pathways
curacin A
Cyclopropanes - chemistry
Cyclopropanes - metabolism
enzymes
Multienzyme Complexes - chemistry
Multienzyme Complexes - genetics
Multigene Family
polyketide synthases
Polyketide Synthases - metabolism
Synergistic effect
Thiazoles - chemistry
Thiazoles - metabolism
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Summary:Synergistic gathering: Biochemical studies reveal a highly efficient strategy in biosynthesis to promote consecutive multienzyme reactions. In the curacin A pathway, catalytic efficiency of a multi‐step modification process and one‐step translocation is significantly enhanced by tandem organization and dimerization of the ACP3 tridomain with an unexpected synergistic effect (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201005280