Are Time- and Event-based Prospective Memory Comparably Affected in HIV Infection?

According to the multi-process theory of prospective memory (ProM), time-based tasks rely more heavily on strategic processes dependent on prefrontal systems than do event-based tasks. Given the prominent frontostriatal pathophysiology of HIV infection, one would expect HIV-infected individuals to d...

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Bibliographic Details
Published in:Archives of clinical neuropsychology 2011-04, Vol.26 (3), p.250-259
Main Authors: ZOGG, Jennifer B, WOODS, Steven Paul, WEBER, Erica, DOYLE, Katie, GRANT, Igor
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Analysis of Variance
Biological and medical sciences
Cognition Disorders - etiology
Cues
Executive Function - physiology
Female
HIV Infections - complications
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Memory Disorders - etiology
Middle Aged
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Original Empirical
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Time Factors
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:According to the multi-process theory of prospective memory (ProM), time-based tasks rely more heavily on strategic processes dependent on prefrontal systems than do event-based tasks. Given the prominent frontostriatal pathophysiology of HIV infection, one would expect HIV-infected individuals to demonstrate greater deficits in time-based versus event-based ProM. However, the two prior studies examining this question have produced variable results. We evaluated this hypothesis in 143 individuals with HIV infection and 43 demographically similar seronegative adults (HIV-) who completed the research version of the Memory for Intentions Screening Test, which yields parallel subscales of time- and event-based ProM. Results showed main effects of HIV serostatus and cue type, but no interaction between serostatus and cue. Planned pair-wise comparisons showed a significant effect of HIV on time-based ProM and a trend-level effect on event-based ProM that was driven primarily by the subset of participants with HIV-associated neurocognitive disorders. Nevertheless, time-based ProM was more strongly correlated with measures of executive functions, attention/working memory, and verbal fluency in HIV-infected persons. Although HIV-associated deficits in time- and event-based ProM appear to be of comparable severity, the cognitive architecture of time-based ProM may be more strongly influenced by strategic monitoring and retrieval processes.
ISSN:0887-6177
1873-5843
DOI:10.1093/arclin/acr020