Apoptotic bone marrow CD34＋ cells in cirrhotic patients

AIM： To access the frequency and level of apoptotic CD34＋ cells isolated from the marrow fluid of patients with post-hepatitis cirrhosis. METHODS： The frequency of bone marrow CD34＋ cells and apoptotic bone marrow CD34＋ cells in 31 inpatients with post-hepatitis cirrhosis （cirrhosis group）, and 15 o...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2011-04, Vol.17 (15), p.2044-2048
Main Authors: Dang, Shuang-Suo, Wang, Wen-Jun, Gao, Ning, Wang, Shun-Da, Li, Mei, Liu, La-Yang, Sun, Ming-Zhun, Dong, Tao
Format: Article
Language:English
Subjects:
Adult
Antigens, CD34 - immunology
Apoptosis - immunology
Bilirubin - blood
Bone Marrow Cells - immunology
Bone Marrow Cells - physiology
Brief
CD34
Female
Hepatitis, Chronic - complications
Hepatitis, Chronic - immunology
Humans
Liver Cirrhosis - blood
Liver Cirrhosis - etiology
Liver Cirrhosis - immunology
Liver Cirrhosis - pathology
Male
Middle Aged
Transaminases - blood
患者
流式细胞仪
细胞凋亡
肝硬化
血液疾病
谷草转氨酶
骨髓细胞
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Summary:AIM： To access the frequency and level of apoptotic CD34＋ cells isolated from the marrow fluid of patients with post-hepatitis cirrhosis. METHODS： The frequency of bone marrow CD34＋ cells and apoptotic bone marrow CD34＋ cells in 31 inpatients with post-hepatitis cirrhosis （cirrhosis group）, and 15 out-patients without liver or blood disorders （control group） was calculated by flow cytometry. Parameters were collected to evaluate liver functions of patients in cirrhosis group. RESULTS： The percentage of normal bone marrow CD34＋ cells was 6.30% ± 2.48% and 1.87% ± 0.53% （t = 3.906, P 0.01） while that of apoptotic marrowCD34＋ cells was 15.00% ± 15.81% and 5.73% ± 1.57% （t = 2.367, P 0.05） in cirrhosis and control groups, respectively. The percentage of apoptotic marrow CD34＋ cells was 6.25% ± 3.30% and 20.92 ± 18.5% （t = 2.409, P 0.05） in Child-Pugh A and Child-Pugh B ＋ C cirrhotic patients, respectively. The percentage of late apoptotic marrow CD34＋ cells was positively correlated with the total bilirubin and aspartate aminotransferase serum levels in patients with cirrhosis. CONCLUSION： The status of CD34＋ marrow cells in cirrhotic patients may suggest that the ability of hematopoietic progenitor cells to transform into mature blood cells is impaired.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v17.i15.2044