Role of bile acid sequestrants in the treatment of type 2 diabetes

Cholestyramine is a first-generation bile acid sequestrant(BAS) and antihyperlipidemic agent that currentl y has limited use because of its relatively weak effect on lowering low density-lipoprotein(LDL)-chol es terol(C) and poor tolerability.The current first choice drugs for hyper-LDL-cholesterole...

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Bibliographic Details
Published in:World journal of diabetes 2010-11, Vol.1 (5), p.146-152
Main Authors: Takebayashi, Kohzo, Aso, Yoshimasa, Inukai, Toshihiko
Format: Article
Language:English
Subjects:
acid
Bile
diabetes
Review
sequestrant
Type
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Summary:Cholestyramine is a first-generation bile acid sequestrant(BAS) and antihyperlipidemic agent that currentl y has limited use because of its relatively weak effect on lowering low density-lipoprotein(LDL)-chol es terol(C) and poor tolerability.The current first choice drugs for hyper-LDL-cholesterolemia are 3-hy droxy-3-me t hyl-glutaryl coenzyme A reductase inhibitors(statins) because of their strong LDL-C lowering effects and efficacy in prevention of card io vascular disease.Howe ver,after lowering the target levels of LDL-C in very high risk patients,combination therapy with statins and other antihyper lipidemic drugs may become more important for treatment of hyper-LDL-cholesterolemia.Second-generation BASs such as coles evelam and colestimide have a glucose-lowering effect and improved tolerance,which has led to re-evaluation of their utility in combination with statins or antidiabetic agents.
ISSN:1948-9358
1948-9358
DOI:10.4239/wjd.v1.i5.146