Regulation of cancer cell migration and invasion by sphingosine-1-phosphate

Sphingosine-1-phosphate (S1P) is a bioactive sphingo-lipid that has been implicated in regulation of a number of cancer cell malignant behaviors, including cell proliferation, survival, chemotherapeutic resistance and angiogenesis. However, the effects of S1P on cancer cell migration, invasion and m...

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Bibliographic Details
Published in:World journal of biological chemistry 2010-10, Vol.1 (10), p.307-312
Main Author: Brocklyn, James R Van
Format: Article
Language:English
Subjects:
Sphingolipids
Cancer
Invasion
Metastasis
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Summary:Sphingosine-1-phosphate (S1P) is a bioactive sphingo-lipid that has been implicated in regulation of a number of cancer cell malignant behaviors, including cell proliferation, survival, chemotherapeutic resistance and angiogenesis. However, the effects of S1P on cancer cell migration, invasion and metastasis, are perhaps its most complex, due to the fact that, depending upon the S1P receptors that mediate its responses and the crosstalk with other signaling pathways, S1P can either positively or negatively regulate invasion. This review summarizes the effects of S1P on cancer cell invasion and the mechanisms by which it affects this important aspect of cancer cell behavior.
ISSN:1949-8454
1949-8454
DOI:10.4331/wjbc.v1.i10.307