Alpha-1-adrenergic receptors: Targets for agonist drugs to treat heart failure

Abstract Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and β-adrenergic receptors are down-regu...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2011-10, Vol.51 (4), p.518-528
Main Authors: Jensen, Brian C, O'Connell, Timothy D, Simpson, Paul C
Format: Article
Language:English
Subjects:
Adrenergic alpha-1 Receptor Agonists - therapeutic use
alpha-1-Adrenergic receptors
Animals
Cardiac myocytes
Cardiovascular
Disease Models, Animal
Drug development
Heart - drug effects
Heart - physiopathology
Heart failure
Heart Failure - drug therapy
Heart Failure - physiopathology
Humans
Molecular Targeted Therapy
Myocardium - metabolism
Receptors, Adrenergic, alpha-1 - genetics
Receptors, Adrenergic, alpha-1 - metabolism
Translational Medical Research
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Summary:Abstract Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and β-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating α1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled “Key Signaling Molecules in Hypertrophy and Heart Failure.”
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2010.11.014