IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton

Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens’ virulence is manipulation of the host cell’s cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein th...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 2011-03, Vol.585 (5), p.723-729
Main Authors: Kim, Hugh, White, Colin D., Sacks, David B.
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Cytoskeleton - metabolism
EPEC
Humans
Infection - metabolism
Infection - microbiology
Infection - virology
IQGAP1
Microbial pathogenesis
Models, Biological
ras GTPase-Activating Proteins - metabolism
Salmonella
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens’ virulence is manipulation of the host cell’s cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades. Research has shown that IQGAP1 binds to and modulates the activity of multiple proteins that participate in bacterial invasion. Here, we review data that support a role for IQGAP1 in infectious disease via its ability to regulate the actin cytoskeleton. In addition, we explore other mechanisms by which IQGAP1 may be exploited by microbial pathogens.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2011.01.041