Localization of asymmetric brain function in emotion and depression

Although numerous EEG studies have shown that depression is associated with abnormal functional asymmetries in frontal cortex, fMRI and PET studies have largely failed to identify specific brain areas showing this effect. The present study tested the hypothesis that emotion processes are related to...

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Bibliographic Details
Published in:Psychophysiology 2010-05, Vol.47 (3), p.442-454
Main Authors: Herrington, John D., Heller, Wendy, Mohanty, Aprajita, Engels, Anna S., Banich, Marie T., Webb, Andrew G., Miller, Gregory A.
Format: Article
Language:English
Subjects:
Affect
Amygdala - physiopathology
Brain - physiopathology
Brain asymmetry
Brain research
Data Interpretation, Statistical
Depression
Depression - physiopathology
Depression - psychology
Electroencephalography
Emotion
Emotions
Emotions - physiology
Female
fMRI
Frontal Lobe - physiopathology
Functional Laterality - physiology
Humans
Information processing
Magnetic Resonance Imaging
Male
Mental depression
Motivation
Neuropsychological Tests
Physiological psychology
Psychomotor Performance - physiology
Young Adult
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Summary:Although numerous EEG studies have shown that depression is associated with abnormal functional asymmetries in frontal cortex, fMRI and PET studies have largely failed to identify specific brain areas showing this effect. The present study tested the hypothesis that emotion processes are related to asymmetric patterns of fMRI activity, particularly within dorsolateral prefrontal cortex (DLPFC). Eleven depressed and 18 control participants identified the color in which pleasant, neutral, and unpleasant words were printed. Both groups showed a leftward lateralization for pleasant words in DLPFC. In a neighboring DLPFC area, the depression group showed more right‐lateralized activation than controls, replicating EEG findings. These data confirm that emotional stimulus processing and trait depression are associated with asymmetric brain functions in distinct subregions of the DLPFC that may go undetected unless appropriate analytic procedures are used.
ISSN:0048-5772
1469-8986
1540-5958
DOI:10.1111/j.1469-8986.2009.00958.x