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Gucosamine-6-sulfamate Analogs of Heparan Sulfate as Inhibitors of Endosulfatases

Keeping Sulfate. The extracellular endosulfatases, which modulate signalling pathways by removing sulfate groups from heparan, can be inhibited by replacing the 6-sulfate destined for cleavage with an inhibitory sulfamate motif, as demonstrated by simple glucosamine-6-sulfamate analogs of heparan su...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2010-11, Vol.11 (17), p.2393-2397
Main Authors: Schelwies, Mathias, Brinson, Diana, Otsuki, Shuhei, Hong, Young-Hoon, Lotz, Martin K., Wong, Chi-Huey, Hanson, Sarah R.
Format: Article
Language:English
Online Access:Get full text
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Summary:Keeping Sulfate. The extracellular endosulfatases, which modulate signalling pathways by removing sulfate groups from heparan, can be inhibited by replacing the 6-sulfate destined for cleavage with an inhibitory sulfamate motif, as demonstrated by simple glucosamine-6-sulfamate analogs of heparan sulfate.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201000401