MYC and Metastasis

Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a large...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2011-03, Vol.71 (6), p.2034-2037
Main Authors: WOLFER, Anita, RAMASWAMY, Sridhar
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Medical sciences
Models, Genetic
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Pharmacology. Drug treatments
Prognosis
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Tumors
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Summary:Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of controversy. We recently found that many prognostic signatures reflect the activity of the MYC oncogene, which in turn regulates tumor metastasis through specific effects on cancer cell invasion and migration. These findings offer a general framework for understanding the molecular basis of clinically prognostic transcriptional signatures and suggest potentially new avenues for studying metastasis.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-10-3776