Multifunctional imaging nanoprobes

Multifunctional imaging nanoprobes have proven to be of great value in the research of pathological processes, as well as the assessment of the delivery, fate, and therapeutic potential of encapsulated drugs. Moreover, such probes may potentially support therapy schemes by the exploitation of their...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2010-03, Vol.2 (2), p.138-150
Main Authors: Jarzyna, Peter A., Gianella, Anita, Skajaa, Torjus, Knudsen, Gitte, Deddens, Lisette H., Cormode, David P., Fayad, Zahi A., Mulder, Willem J. M.
Format: Article
Language:English
Subjects:
Ablation
Animals
Assessments
Biosensors
Chemical compounds
Diagnostic Imaging - methods
Diagnostic software
Diagnostic systems
Drug Delivery Systems
Drugs
Exploitation
Fluorescence
Fluorophores
Gene Transfer Techniques
Humans
Imaging
Imaging techniques
Lipids
Molecular Probes - metabolism
Nanocomposites
Nanomaterials
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Nanotechnology
Nucleic acids
Peptides
Physical properties
Polymers
Probes
Proteins
Temperature
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Summary:Multifunctional imaging nanoprobes have proven to be of great value in the research of pathological processes, as well as the assessment of the delivery, fate, and therapeutic potential of encapsulated drugs. Moreover, such probes may potentially support therapy schemes by the exploitation of their own physical properties, e.g., through thermal ablation. This review will present four classes of nanoparticulate imaging probes used in this area: multifunctional probes (1) that can be tracked with at least three different and complementary imaging techniques, (2) that carry a drug and have bimodal imaging properties, (3) that are employed for nucleic acid delivery and imaging, and (4) imaging probes with capabilities that can be used for thermal ablation. We will highlight several examples where the suitable combination of different (bio)materials like polymers, inorganic nanocrystals, fluorophores, proteins/peptides, and lipids can be tailored to manufacture multifunctional probes to accomplish nanomaterials of each of the aforementioned classes. Moreover, it will be demonstrated how multimodality imaging approaches improve our understanding of in vivo nanoparticle behavior and efficacy at different levels, ranging from the subcellular level to the whole body. WIREs Nanomed Nanobiotechnol 2010 2 138–150 This article is categorized under: Diagnostic Tools > Biosensing
ISSN:1939-5116
1939-0041
1939-0041
DOI:10.1002/wnan.72