Marginal zone B cells regulate antigen capture by marginal zone macrophages

The marginal zone (MZ) of the mouse spleen contains macrophages that express receptors that trap pathogens, including the scavenger receptor macrophage receptor with a collagenous structure and the C-type lectin specific intracellular adhesion molecule-grabbing nonintegrin receptor 1 (SIGN-R1). We p...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2011-02, Vol.186 (4), p.2172-2181
Main Authors: You, Yuying, Myers, Riley C, Freeberg, Larry, Foote, Jeremy, Kearney, John F, Justement, Louis B, Carter, Robert H
Format: Article
Language:English
Subjects:
Animals
Antigens - genetics
Antigens - metabolism
Antigens, CD19 - genetics
B-Lymphocyte Subsets - cytology
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Cell Adhesion Molecules - deficiency
Cell Adhesion Molecules - genetics
Cell Differentiation - genetics
Cell Differentiation - immunology
Cell Movement - genetics
Cell Movement - immunology
Lectins, C-Type - deficiency
Lectins, C-Type - genetics
Macrophages - cytology
Macrophages - immunology
Macrophages - metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Receptors, Cell Surface - deficiency
Receptors, Cell Surface - genetics
Spleen - cytology
Spleen - immunology
Spleen - metabolism
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Summary:The marginal zone (MZ) of the mouse spleen contains macrophages that express receptors that trap pathogens, including the scavenger receptor macrophage receptor with a collagenous structure and the C-type lectin specific intracellular adhesion molecule-grabbing nonintegrin receptor 1 (SIGN-R1). We previously reported that expression of SIGN-R1 was decreased in CD19-deficient mice. In this study, we demonstrate that SIGN-R1 is expressed on a subset of macrophage receptor with a collagenous structure (MARCO)(+) macrophages. This subset is diminished when MZ B cells are absent due to either genetic developmental defects or following transient migration of B cells out of the MZ. When B cells return to the MZ, there is a delay in recovery of SIGN-R1-expressing macrophages. During this period, capture of Ficoll, which for the macrophages requires SIGN-R1, remains defective not only by the macrophages, but also by the B cells. Thus, MZ B cells regulate expression of molecules on macrophages that are important for trapping Ag, which, in turn, is required for Ag capture by the B cells.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1002106