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fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth
Only four prp (pre-mRNA processing) genes of the fission yeast Schizosaccharomyces pombe have been reported. We exploited yeast genetics and identified and isolated the prp4 gene. Sequence analysis revealed that the splicing factor encoded by this gene contains the signature sequences that define th...
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| Published in: | Nucleic acids research 1993-08, Vol.21 (17), p.4079-4083 |
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| Language: | English |
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| container_end_page | 4083 |
| container_issue | 17 |
| container_start_page | 4079 |
| container_title | Nucleic acids research |
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| creator | Alahari, S.K Schmidt, H Kaufer, N.F |
| description | Only four prp (pre-mRNA processing) genes of the fission yeast Schizosaccharomyces pombe have been reported. We exploited yeast genetics and identified and isolated the prp4 gene. Sequence analysis revealed that the splicing factor encoded by this gene contains the signature sequences that define the serine/threonine protein kinase family. This is the first kinase gene identified whose product is involved in pre-mRNA splicing. The prp4 gene contains one intron in the kinase domain. Gene replacement studies provided evidence that this gene is essential for growth and is located on chromosome III. |
| doi_str_mv | 10.1093/nar/21.17.4079 |
| format | article |
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We exploited yeast genetics and identified and isolated the prp4 gene. Sequence analysis revealed that the splicing factor encoded by this gene contains the signature sequences that define the serine/threonine protein kinase family. This is the first kinase gene identified whose product is involved in pre-mRNA splicing. The prp4 gene contains one intron in the kinase domain. Gene replacement studies provided evidence that this gene is essential for growth and is located on chromosome III.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/21.17.4079</identifier><identifier>PMID: 8371982</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>alternative splicing ; Amino Acid Sequence ; amino acid sequences ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; Blotting, Southern ; DNA, Fungal ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - genetics ; genbank/l10739 ; Genes, Fungal ; Genes. Genome ; Genetic Complementation Test ; Introns ; messenger RNA ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; nucleotide sequences ; precursors ; Protein-Serine-Threonine Kinases - genetics ; Restriction Mapping ; Ribonucleoprotein, U4-U6 Small Nuclear - genetics ; RNA Precursors - metabolism ; RNA Splicing - genetics ; Saccharomycetales ; Schizosaccharomyces - enzymology ; Schizosaccharomyces - genetics ; Schizosaccharomyces - growth & development ; Schizosaccharomyces pombe ; Sequence Homology, Amino Acid ; serine ; structural genes ; Suppression, Genetic ; threonine ; Transcription, Genetic</subject><ispartof>Nucleic acids research, 1993-08, Vol.21 (17), p.4079-4083</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4569-c97d4e892f47beb364156de769c3a5e882914d1c0a0e16ab3c1bf689fab7d8dc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC310008/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC310008/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4887553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8371982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alahari, S.K</creatorcontrib><creatorcontrib>Schmidt, H</creatorcontrib><creatorcontrib>Kaufer, N.F</creatorcontrib><title>fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>Only four prp (pre-mRNA processing) genes of the fission yeast Schizosaccharomyces pombe have been reported. We exploited yeast genetics and identified and isolated the prp4 gene. Sequence analysis revealed that the splicing factor encoded by this gene contains the signature sequences that define the serine/threonine protein kinase family. This is the first kinase gene identified whose product is involved in pre-mRNA splicing. The prp4 gene contains one intron in the kinase domain. Gene replacement studies provided evidence that this gene is essential for growth and is located on chromosome III.</description><subject>alternative splicing</subject><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Blotting, Southern</subject><subject>DNA, Fungal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal Proteins - genetics</subject><subject>genbank/l10739</subject><subject>Genes, Fungal</subject><subject>Genes. Genome</subject><subject>Genetic Complementation Test</subject><subject>Introns</subject><subject>messenger RNA</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>nucleotide sequences</subject><subject>precursors</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Restriction Mapping</subject><subject>Ribonucleoprotein, U4-U6 Small Nuclear - genetics</subject><subject>RNA Precursors - metabolism</subject><subject>RNA Splicing - genetics</subject><subject>Saccharomycetales</subject><subject>Schizosaccharomyces - enzymology</subject><subject>Schizosaccharomyces - genetics</subject><subject>Schizosaccharomyces - growth & development</subject><subject>Schizosaccharomyces pombe</subject><subject>Sequence Homology, Amino Acid</subject><subject>serine</subject><subject>structural genes</subject><subject>Suppression, Genetic</subject><subject>threonine</subject><subject>Transcription, Genetic</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNpVkkFvEzEQhVcIVELhyg3hA-KCNrXX3rV96KGtIAVFgIBKiIs1651NTDd2sDeB3vjpOCSK4OSR3_dmxnouiqeMThnV_MxDPKvYlMmpoFLfKyaMN1UpdFPdLyaU07pkVKiHxaOUvlPKBKvFSXGiuGRaVZPid-9ScsGTO4Q0knVci1dkgR6J89swbLHLRb7GcvXp_QVJ68FZ5xfEhg4T6UMksFM7Z8eMJozO49m4jBh8rsit85CQgM9tEsGU0I8Ohr_GRQw_x-Xj4kEPQ8Inh_O0uHnz-svVdTn_MHt7dTEvragbXVotO4FKV72QLba8yQ9pOpSNthxqVKrSTHTMUqDIGmi5ZW3fKN1DKzvVWX5anO_7rjftCjubF4kwmHV0K4h3JoAz_yveLc0ibA1nlFKV_S8P_hh-bDCNZuWSxWEAj2GTjKx1Q2tRZ3C6B20MKUXsjzMYNbvITI7MVMwwaXaRZcOzfzc74oeMsv7ioEOyMPQRvHXpiAmlZF3zjJV7zKURfx1liLemkVzW5vrrNzOby8uP72bUXGb--Z7vIRhYxNzy5nNFGc-fRLFKCf4HXU66jA</recordid><startdate>19930825</startdate><enddate>19930825</enddate><creator>Alahari, S.K</creator><creator>Schmidt, H</creator><creator>Kaufer, N.F</creator><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930825</creationdate><title>fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth</title><author>Alahari, S.K ; Schmidt, H ; Kaufer, N.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4569-c97d4e892f47beb364156de769c3a5e882914d1c0a0e16ab3c1bf689fab7d8dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>alternative splicing</topic><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Blotting, Southern</topic><topic>DNA, Fungal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal Proteins - genetics</topic><topic>genbank/l10739</topic><topic>Genes, Fungal</topic><topic>Genes. Genome</topic><topic>Genetic Complementation Test</topic><topic>Introns</topic><topic>messenger RNA</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>nucleotide sequences</topic><topic>precursors</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Restriction Mapping</topic><topic>Ribonucleoprotein, U4-U6 Small Nuclear - genetics</topic><topic>RNA Precursors - metabolism</topic><topic>RNA Splicing - genetics</topic><topic>Saccharomycetales</topic><topic>Schizosaccharomyces - enzymology</topic><topic>Schizosaccharomyces - genetics</topic><topic>Schizosaccharomyces - growth & development</topic><topic>Schizosaccharomyces pombe</topic><topic>Sequence Homology, Amino Acid</topic><topic>serine</topic><topic>structural genes</topic><topic>Suppression, Genetic</topic><topic>threonine</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alahari, S.K</creatorcontrib><creatorcontrib>Schmidt, H</creatorcontrib><creatorcontrib>Kaufer, N.F</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alahari, S.K</au><au>Schmidt, H</au><au>Kaufer, N.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>1993-08-25</date><risdate>1993</risdate><volume>21</volume><issue>17</issue><spage>4079</spage><epage>4083</epage><pages>4079-4083</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>Only four prp (pre-mRNA processing) genes of the fission yeast Schizosaccharomyces pombe have been reported. We exploited yeast genetics and identified and isolated the prp4 gene. Sequence analysis revealed that the splicing factor encoded by this gene contains the signature sequences that define the serine/threonine protein kinase family. This is the first kinase gene identified whose product is involved in pre-mRNA splicing. The prp4 gene contains one intron in the kinase domain. Gene replacement studies provided evidence that this gene is essential for growth and is located on chromosome III.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8371982</pmid><doi>10.1093/nar/21.17.4079</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nucleic acids research, 1993-08, Vol.21 (17), p.4079-4083 |
| issn | 0305-1048 1362-4962 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_310008 |
| source | Open Access: PubMed Central; Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025 |
| subjects | alternative splicing Amino Acid Sequence amino acid sequences Base Sequence Biological and medical sciences Blotting, Northern Blotting, Southern DNA, Fungal Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics genbank/l10739 Genes, Fungal Genes. Genome Genetic Complementation Test Introns messenger RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data nucleotide sequences precursors Protein-Serine-Threonine Kinases - genetics Restriction Mapping Ribonucleoprotein, U4-U6 Small Nuclear - genetics RNA Precursors - metabolism RNA Splicing - genetics Saccharomycetales Schizosaccharomyces - enzymology Schizosaccharomyces - genetics Schizosaccharomyces - growth & development Schizosaccharomyces pombe Sequence Homology, Amino Acid serine structural genes Suppression, Genetic threonine Transcription, Genetic |
| title | fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth |
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