Dynamics of epileptiform activity in mouse hippocampal slices

Increase of the extracellular K  +  concentration mediates seizure-like synchronized activities in vitro and was proposed to be one of the main factors underlying epileptogenesis in some types of seizures in vivo. While underlying biophysical mechanisms clearly involve cell depolarization and overal...

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Bibliographic Details
Published in:Journal of biological physics 2011-06, Vol.37 (3), p.347-360
Main Authors: Filatov, Gregory, Krishnan, Giri P., Rulkov, Nikolai F., Bazhenov, Maxim
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biophysics
Brain
Brain slice preparation
Complex Fluids and Microfluidics
Complex Systems
Data processing
Epilepsy
Evolution
Excitability
Neurosciences
Original Paper
Physics
Physics and Astronomy
Potassium
Rodents
Seizures
Soft and Granular Matter
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Summary:Increase of the extracellular K  +  concentration mediates seizure-like synchronized activities in vitro and was proposed to be one of the main factors underlying epileptogenesis in some types of seizures in vivo. While underlying biophysical mechanisms clearly involve cell depolarization and overall increase in excitability, it remains unknown what qualitative changes of the spatio-temporal network dynamics occur after extracellular K  +  increase. In this study, we used multi-electrode recordings from mouse hippocampal slices to explore changes of the network activity during progressive increase of the extracellular K  +  concentration. Our analysis revealed complex spatio-temporal evolution of epileptiform activity and demonstrated a sequence of state transitions from relatively simple network bursts into complex bursting, with multiple synchronized events within each burst. We describe these transitions as qualitative changes of the state attractors, constructed from experimental data, mediated by elevation of extracellular K  +  concentration.
ISSN:0092-0606
1573-0689
DOI:10.1007/s10867-011-9216-x