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Disseminated tumour cells as a prognostic biomarker in colorectal cancer
Background: The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC). Methods: The study population consisted of 235 patients with CRC prospectively recruited from fiv...
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| Published in: | British journal of cancer 2011-04, Vol.104 (9), p.1434-1439 |
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| Main Authors: | , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c498t-dc9ed7456ae3f8ec15560944afebe31b3c76d74b364e36c5b0769bfc7633f3413 |
| container_end_page | 1439 |
| container_issue | 9 |
| container_start_page | 1434 |
| container_title | British journal of cancer |
| container_volume | 104 |
| creator | Flatmark, K Borgen, E Nesland, J M Rasmussen, H Johannessen, H-O Bukholm, I Rosales, R Hårklau, L Jacobsen, H J Sandstad, B Boye, K Fodstad, Ø |
| description | Background:
The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC).
Methods:
The study population consisted of 235 patients with CRC prospectively recruited from five hospitals in the Oslo region. Bone marrow (BM) aspirates were collected at the time of surgery and the presence of DTC was determined by two immunological methods; immunomagnetic selection (using an anti-EpCAM antibody) and immunocytochemistry (using a pan-cytokeratin antibody). Associations between the presence of DTC and metastasis-free, disease-specific and overall survival were analysed using univariate and multivariate methods.
Results:
Disseminated tumour cells were detected in 41 (17%) and 28 (12%) of the 235 examined BM samples by immunomagnetic selection and immunocytochemistry, respectively, with only five samples being positive with both methods. The presence of DTC was associated with adverse outcome (metastasis-free, disease-specific and overall survival) in univariate and multivariate analyses.
Conclusion:
The presence of DTC was associated with adverse prognosis in this cohort of patients curatively resected for CRC, suggesting that DTC detection still holds promise as a biomarker in CRC. |
| doi_str_mv | 10.1038/bjc.2011.97 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3101945</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2330397631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-dc9ed7456ae3f8ec15560944afebe31b3c76d74b364e36c5b0769bfc7633f3413</originalsourceid><addsrcrecordid>eNptkdGL1DAQxoMo3t7pk-9aBPFBu2aatGleBLlTTzjwRZ9Dmp2uWdtkL2kF_3un7LqnIgRCMj---WY-xp4AXwMX7Ztu59YVB1hrdY-toBZVCW2l7rMV51yVXFf8jJ3nvKOn5q16yM4qkLIFBSt2feVzxtEHO-GmmOYxzqlwOAy5sHSKfYrbEPPkXdH5ONr0HVPhQ-HiEBO6yQ6Fs8FhesQe9HbI-Ph4X7CvH95_ubwubz5__HT57qZ0UrdTuXEaN0rWjUXRt-igrhuupbQ9diigE041VO9EI1E0ru64anTX068QvZAgLtjbg-5-7kbcOAxTsoPZJ0_mfppovfm7Evw3s40_jAAOWtYk8PIokOLtjHkyo8_LxDZgnLNpG6Fpm1wR-fwfckfbCTTdAtWyalVF0KsD5FLMOWF_sgLcLPkYyscs-Ri9SD790_2J_R0IAS-OgM3ODn2i5fp8x0mQSsMyxesDl6kUtpjuvP2_77MDTjnPCU96xCwIEb8A-P6ybQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>863542872</pqid></control><display><type>article</type><title>Disseminated tumour cells as a prognostic biomarker in colorectal cancer</title><source>PubMed Central Free</source><creator>Flatmark, K ; Borgen, E ; Nesland, J M ; Rasmussen, H ; Johannessen, H-O ; Bukholm, I ; Rosales, R ; Hårklau, L ; Jacobsen, H J ; Sandstad, B ; Boye, K ; Fodstad, Ø</creator><creatorcontrib>Flatmark, K ; Borgen, E ; Nesland, J M ; Rasmussen, H ; Johannessen, H-O ; Bukholm, I ; Rosales, R ; Hårklau, L ; Jacobsen, H J ; Sandstad, B ; Boye, K ; Fodstad, Ø</creatorcontrib><description>Background:
The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC).
Methods:
The study population consisted of 235 patients with CRC prospectively recruited from five hospitals in the Oslo region. Bone marrow (BM) aspirates were collected at the time of surgery and the presence of DTC was determined by two immunological methods; immunomagnetic selection (using an anti-EpCAM antibody) and immunocytochemistry (using a pan-cytokeratin antibody). Associations between the presence of DTC and metastasis-free, disease-specific and overall survival were analysed using univariate and multivariate methods.
Results:
Disseminated tumour cells were detected in 41 (17%) and 28 (12%) of the 235 examined BM samples by immunomagnetic selection and immunocytochemistry, respectively, with only five samples being positive with both methods. The presence of DTC was associated with adverse outcome (metastasis-free, disease-specific and overall survival) in univariate and multivariate analyses.
Conclusion:
The presence of DTC was associated with adverse prognosis in this cohort of patients curatively resected for CRC, suggesting that DTC detection still holds promise as a biomarker in CRC.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2011.97</identifier><identifier>PMID: 21448171</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2422 ; 692/699/67/1504/1885 ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Antibodies ; Antigens, Neoplasm - analysis ; Biological and medical sciences ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Bone marrow ; Bone Marrow - pathology ; Cancer Research ; Cell Adhesion Molecules - analysis ; Colorectal cancer ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Cytokeratin ; Disease-Free Survival ; Drug Resistance ; Epidemiology ; Epithelial Cell Adhesion Molecule ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hospitals ; Humans ; Immunohistochemistry ; Immunomagnetic Separation ; Kaplan-Meier Estimate ; Keratins - analysis ; Male ; Medical prognosis ; Medical research ; Medical sciences ; Metastasis ; Middle Aged ; Molecular Diagnostics ; Molecular Medicine ; Neoplasm Staging ; Neoplastic Cells, Circulating - pathology ; Norway ; Oncology ; Patients ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Tumors</subject><ispartof>British journal of cancer, 2011-04, Vol.104 (9), p.1434-1439</ispartof><rights>The Author(s) 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 26, 2011</rights><rights>Copyright © 2011 Cancer Research UK 2011 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-dc9ed7456ae3f8ec15560944afebe31b3c76d74b364e36c5b0769bfc7633f3413</citedby><cites>FETCH-LOGICAL-c498t-dc9ed7456ae3f8ec15560944afebe31b3c76d74b364e36c5b0769bfc7633f3413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101945/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101945/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24147915$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21448171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flatmark, K</creatorcontrib><creatorcontrib>Borgen, E</creatorcontrib><creatorcontrib>Nesland, J M</creatorcontrib><creatorcontrib>Rasmussen, H</creatorcontrib><creatorcontrib>Johannessen, H-O</creatorcontrib><creatorcontrib>Bukholm, I</creatorcontrib><creatorcontrib>Rosales, R</creatorcontrib><creatorcontrib>Hårklau, L</creatorcontrib><creatorcontrib>Jacobsen, H J</creatorcontrib><creatorcontrib>Sandstad, B</creatorcontrib><creatorcontrib>Boye, K</creatorcontrib><creatorcontrib>Fodstad, Ø</creatorcontrib><title>Disseminated tumour cells as a prognostic biomarker in colorectal cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC).
Methods:
The study population consisted of 235 patients with CRC prospectively recruited from five hospitals in the Oslo region. Bone marrow (BM) aspirates were collected at the time of surgery and the presence of DTC was determined by two immunological methods; immunomagnetic selection (using an anti-EpCAM antibody) and immunocytochemistry (using a pan-cytokeratin antibody). Associations between the presence of DTC and metastasis-free, disease-specific and overall survival were analysed using univariate and multivariate methods.
Results:
Disseminated tumour cells were detected in 41 (17%) and 28 (12%) of the 235 examined BM samples by immunomagnetic selection and immunocytochemistry, respectively, with only five samples being positive with both methods. The presence of DTC was associated with adverse outcome (metastasis-free, disease-specific and overall survival) in univariate and multivariate analyses.
Conclusion:
The presence of DTC was associated with adverse prognosis in this cohort of patients curatively resected for CRC, suggesting that DTC detection still holds promise as a biomarker in CRC.</description><subject>692/53/2422</subject><subject>692/699/67/1504/1885</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Antibodies</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone marrow</subject><subject>Bone Marrow - pathology</subject><subject>Cancer Research</subject><subject>Cell Adhesion Molecules - analysis</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Cytokeratin</subject><subject>Disease-Free Survival</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Epithelial Cell Adhesion Molecule</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunomagnetic Separation</subject><subject>Kaplan-Meier Estimate</subject><subject>Keratins - analysis</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Neoplasm Staging</subject><subject>Neoplastic Cells, Circulating - pathology</subject><subject>Norway</subject><subject>Oncology</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNptkdGL1DAQxoMo3t7pk-9aBPFBu2aatGleBLlTTzjwRZ9Dmp2uWdtkL2kF_3un7LqnIgRCMj---WY-xp4AXwMX7Ztu59YVB1hrdY-toBZVCW2l7rMV51yVXFf8jJ3nvKOn5q16yM4qkLIFBSt2feVzxtEHO-GmmOYxzqlwOAy5sHSKfYrbEPPkXdH5ONr0HVPhQ-HiEBO6yQ6Fs8FhesQe9HbI-Ph4X7CvH95_ubwubz5__HT57qZ0UrdTuXEaN0rWjUXRt-igrhuupbQ9diigE041VO9EI1E0ru64anTX068QvZAgLtjbg-5-7kbcOAxTsoPZJ0_mfppovfm7Evw3s40_jAAOWtYk8PIokOLtjHkyo8_LxDZgnLNpG6Fpm1wR-fwfckfbCTTdAtWyalVF0KsD5FLMOWF_sgLcLPkYyscs-Ri9SD790_2J_R0IAS-OgM3ODn2i5fp8x0mQSsMyxesDl6kUtpjuvP2_77MDTjnPCU96xCwIEb8A-P6ybQ</recordid><startdate>20110426</startdate><enddate>20110426</enddate><creator>Flatmark, K</creator><creator>Borgen, E</creator><creator>Nesland, J M</creator><creator>Rasmussen, H</creator><creator>Johannessen, H-O</creator><creator>Bukholm, I</creator><creator>Rosales, R</creator><creator>Hårklau, L</creator><creator>Jacobsen, H J</creator><creator>Sandstad, B</creator><creator>Boye, K</creator><creator>Fodstad, Ø</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110426</creationdate><title>Disseminated tumour cells as a prognostic biomarker in colorectal cancer</title><author>Flatmark, K ; Borgen, E ; Nesland, J M ; Rasmussen, H ; Johannessen, H-O ; Bukholm, I ; Rosales, R ; Hårklau, L ; Jacobsen, H J ; Sandstad, B ; Boye, K ; Fodstad, Ø</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-dc9ed7456ae3f8ec15560944afebe31b3c76d74b364e36c5b0769bfc7633f3413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>692/53/2422</topic><topic>692/699/67/1504/1885</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Antibodies</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone marrow</topic><topic>Bone Marrow - pathology</topic><topic>Cancer Research</topic><topic>Cell Adhesion Molecules - analysis</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Cytokeratin</topic><topic>Disease-Free Survival</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Epithelial Cell Adhesion Molecule</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunomagnetic Separation</topic><topic>Kaplan-Meier Estimate</topic><topic>Keratins - analysis</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Neoplasm Staging</topic><topic>Neoplastic Cells, Circulating - pathology</topic><topic>Norway</topic><topic>Oncology</topic><topic>Patients</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flatmark, K</creatorcontrib><creatorcontrib>Borgen, E</creatorcontrib><creatorcontrib>Nesland, J M</creatorcontrib><creatorcontrib>Rasmussen, H</creatorcontrib><creatorcontrib>Johannessen, H-O</creatorcontrib><creatorcontrib>Bukholm, I</creatorcontrib><creatorcontrib>Rosales, R</creatorcontrib><creatorcontrib>Hårklau, L</creatorcontrib><creatorcontrib>Jacobsen, H J</creatorcontrib><creatorcontrib>Sandstad, B</creatorcontrib><creatorcontrib>Boye, K</creatorcontrib><creatorcontrib>Fodstad, Ø</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flatmark, K</au><au>Borgen, E</au><au>Nesland, J M</au><au>Rasmussen, H</au><au>Johannessen, H-O</au><au>Bukholm, I</au><au>Rosales, R</au><au>Hårklau, L</au><au>Jacobsen, H J</au><au>Sandstad, B</au><au>Boye, K</au><au>Fodstad, Ø</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disseminated tumour cells as a prognostic biomarker in colorectal cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2011-04-26</date><risdate>2011</risdate><volume>104</volume><issue>9</issue><spage>1434</spage><epage>1439</epage><pages>1434-1439</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC).
Methods:
The study population consisted of 235 patients with CRC prospectively recruited from five hospitals in the Oslo region. Bone marrow (BM) aspirates were collected at the time of surgery and the presence of DTC was determined by two immunological methods; immunomagnetic selection (using an anti-EpCAM antibody) and immunocytochemistry (using a pan-cytokeratin antibody). Associations between the presence of DTC and metastasis-free, disease-specific and overall survival were analysed using univariate and multivariate methods.
Results:
Disseminated tumour cells were detected in 41 (17%) and 28 (12%) of the 235 examined BM samples by immunomagnetic selection and immunocytochemistry, respectively, with only five samples being positive with both methods. The presence of DTC was associated with adverse outcome (metastasis-free, disease-specific and overall survival) in univariate and multivariate analyses.
Conclusion:
The presence of DTC was associated with adverse prognosis in this cohort of patients curatively resected for CRC, suggesting that DTC detection still holds promise as a biomarker in CRC.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21448171</pmid><doi>10.1038/bjc.2011.97</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/53/2422 692/699/67/1504/1885 Adult Aged Aged, 80 and over Analysis of Variance Antibodies Antigens, Neoplasm - analysis Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow - pathology Cancer Research Cell Adhesion Molecules - analysis Colorectal cancer Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Cytokeratin Disease-Free Survival Drug Resistance Epidemiology Epithelial Cell Adhesion Molecule Female Gastroenterology. Liver. Pancreas. Abdomen Hospitals Humans Immunohistochemistry Immunomagnetic Separation Kaplan-Meier Estimate Keratins - analysis Male Medical prognosis Medical research Medical sciences Metastasis Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Staging Neoplastic Cells, Circulating - pathology Norway Oncology Patients Predictive Value of Tests Prognosis Prospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Tumors |
| title | Disseminated tumour cells as a prognostic biomarker in colorectal cancer |
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