Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

Purpose. There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods. We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which...

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Bibliographic Details
Published in:ISRN obstetrics and gynecology 2011, Vol.2011 (2011), p.1-11
Main Authors: Kusonoki, Yoichiro, Nakachi, Kei, Fujiwara, Saeko, Akahoshi, Masazumi, Neriishi, Kazuo, Miles, Edward F., Seed, Thomas, Kodama, Yoshiaki, Nakashima, Eiji, Tatsukawa, Yoshimi, Funamoto, Sachiyo, Kamada, Naoko
Format: Article
Language:English
Subjects:
Biological markers
Cancer
Care and treatment
CD4 antigen
Demographic aspects
Diagnosis
Health aspects
Identification and classification
Mutation
Pregnancy
Pregnant women
Radiation injuries
Studies
Womens health
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Summary:Purpose. There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods. We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results/Conclusions. Data on approximately 250 women were available to assess dose-response rates for serum cholesterol, white blood cell count, erythrocyte sedimentation rate, and serum hemoglobin, and on approximately 85 women for stable chromosome aberrations, glycophorin A locus mutations, and naïve CD4 T-cell counts. Although there is no statistically significant evidence of increased radiosensitivity in pregnant women, the increased slope of the linear trend line in the third trimester with respect to stable chromosome aberrations is suggestive of an increased radiosensitivity.
ISSN:2090-4436
2090-4444
DOI:10.5402/2011/264978