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Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis
An enhanced expression of the inflammatory mediators in the perimeniscal synovium in knee osteoarthritis (OA) has been suggested to contribute to progressive cartilage degeneration. However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. M...
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Published in: | International orthopaedics 2011-06, Vol.35 (6), p.831-838 |
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creator | Ning, Liang Ishijima, Muneaki Kaneko, Haruka Kurihara, Hidetake Arikawa-Hirasawa, Eri Kubota, Mitsuaki Liu, Lizu Xu, Zhuo Futami, Ippei Yusup, Anwarjan Miyahara, Katsumi Xu, Shouyu Kaneko, Kazuo Kurosawa, Hisashi |
description | An enhanced expression of the inflammatory mediators in the perimeniscal synovium in knee osteoarthritis (OA) has been suggested to contribute to progressive cartilage degeneration. However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. Medial perimeniscal synovial samples were obtained from 23 patients with Kellgren-Lawrence (K/L) grades 2 to 4 of medial knee OA. Immunohistochemical analysis of the synovium revealed that the MMP-1, COX-2 and IL-1β expression of the patients with K/L 4 to be significantly reduced in comparison to those with either K/L 2 or 3, while the TGF-β expression showed the opposite. The synovial expression of MMP-1 and IL-1β showed a significant negative correlation with the severity of OA, while that of TGF-β again showed the opposite. In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1β expression in synovium decreased depending upon the severity of OA, while the TGF-β expression increased. |
doi_str_mv | 10.1007/s00264-010-1045-1 |
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However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. Medial perimeniscal synovial samples were obtained from 23 patients with Kellgren-Lawrence (K/L) grades 2 to 4 of medial knee OA. Immunohistochemical analysis of the synovium revealed that the MMP-1, COX-2 and IL-1β expression of the patients with K/L 4 to be significantly reduced in comparison to those with either K/L 2 or 3, while the TGF-β expression showed the opposite. The synovial expression of MMP-1 and IL-1β showed a significant negative correlation with the severity of OA, while that of TGF-β again showed the opposite. In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1β expression in synovium decreased depending upon the severity of OA, while the TGF-β expression increased.</description><identifier>ISSN: 0341-2695</identifier><identifier>EISSN: 1432-5195</identifier><identifier>DOI: 10.1007/s00264-010-1045-1</identifier><identifier>PMID: 20517696</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Aged, 80 and over ; Cartilage diseases ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-2 ; Degeneration ; Female ; Growth factors ; Humans ; Inflammation ; Inflammation Mediators - metabolism ; Interleukin-1beta - metabolism ; Interstitial collagenase ; Knee ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 1 - metabolism ; Medicine ; Medicine & Public Health ; Menisci, Tibial - metabolism ; Menisci, Tibial - pathology ; Menisci, Tibial - physiopathology ; Middle Aged ; Original Paper ; Orthopedics ; Osteoarthritis ; Osteoarthritis, Knee - metabolism ; Osteoarthritis, Knee - pathology ; Osteoarthritis, Knee - physiopathology ; Severity of Illness Index ; Synovial Membrane - metabolism ; Synovial Membrane - pathology ; Synovial Membrane - physiopathology ; Synovitis - metabolism ; Synovitis - pathology ; Synovitis - physiopathology ; Synovium ; Transforming Growth Factor beta - metabolism</subject><ispartof>International orthopaedics, 2011-06, Vol.35 (6), p.831-838</ispartof><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-ce825f3d189b107cf3d368c6d4c793e2d193198be2710d8393809dccdd6e5ecf3</citedby><cites>FETCH-LOGICAL-c540t-ce825f3d189b107cf3d368c6d4c793e2d193198be2710d8393809dccdd6e5ecf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103960/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103960/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20517696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ning, Liang</creatorcontrib><creatorcontrib>Ishijima, Muneaki</creatorcontrib><creatorcontrib>Kaneko, Haruka</creatorcontrib><creatorcontrib>Kurihara, Hidetake</creatorcontrib><creatorcontrib>Arikawa-Hirasawa, Eri</creatorcontrib><creatorcontrib>Kubota, Mitsuaki</creatorcontrib><creatorcontrib>Liu, Lizu</creatorcontrib><creatorcontrib>Xu, Zhuo</creatorcontrib><creatorcontrib>Futami, Ippei</creatorcontrib><creatorcontrib>Yusup, Anwarjan</creatorcontrib><creatorcontrib>Miyahara, Katsumi</creatorcontrib><creatorcontrib>Xu, Shouyu</creatorcontrib><creatorcontrib>Kaneko, Kazuo</creatorcontrib><creatorcontrib>Kurosawa, Hisashi</creatorcontrib><title>Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis</title><title>International orthopaedics</title><addtitle>International Orthopaedics (SICOT)</addtitle><addtitle>Int Orthop</addtitle><description>An enhanced expression of the inflammatory mediators in the perimeniscal synovium in knee osteoarthritis (OA) has been suggested to contribute to progressive cartilage degeneration. However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. Medial perimeniscal synovial samples were obtained from 23 patients with Kellgren-Lawrence (K/L) grades 2 to 4 of medial knee OA. Immunohistochemical analysis of the synovium revealed that the MMP-1, COX-2 and IL-1β expression of the patients with K/L 4 to be significantly reduced in comparison to those with either K/L 2 or 3, while the TGF-β expression showed the opposite. The synovial expression of MMP-1 and IL-1β showed a significant negative correlation with the severity of OA, while that of TGF-β again showed the opposite. In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1β expression in synovium decreased depending upon the severity of OA, while the TGF-β expression increased.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cartilage diseases</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase-2</subject><subject>Degeneration</subject><subject>Female</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin-1beta - metabolism</subject><subject>Interstitial collagenase</subject><subject>Knee</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 1 - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menisci, Tibial - metabolism</subject><subject>Menisci, Tibial - pathology</subject><subject>Menisci, Tibial - physiopathology</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Orthopedics</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - metabolism</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Synovial Membrane - metabolism</subject><subject>Synovial Membrane - pathology</subject><subject>Synovial Membrane - physiopathology</subject><subject>Synovitis - metabolism</subject><subject>Synovitis - pathology</subject><subject>Synovitis - physiopathology</subject><subject>Synovium</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>0341-2695</issn><issn>1432-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kk1v1DAQhiMEokvhB3BBvsElMM53LkhoxZdUiQucLceZ7Lok9uJxtt2fxT9k0iwVXHry2O_zznjsSZKXEt5KgPodAWRVkYKEVEJRpvJRspFFnqWlbMvHyQbyQqZZ1ZYXyTOiawBZV418mlxkUHLYVpvk99aHgKOO1jsSHcYbRCc6H_ci7lHg7SEgEYtixCOOJPwgrBtGPU06-nASE_Z2iUho14td8DdsHbThIwZXeRQHDHZCZ8nwhk7OH5fTaIlmvDMuxYgrBBtPS42z76dDFJ4ieh3inkVLz5Mngx4JX5zXy-THp4_ft1_Sq2-fv24_XKWmLCCmBpusHPJeNm0noTYc5lVjqr4wdZtj1ss2l23TYVZL6Ju8zRtoe2P6vsISGb9M3q95D3PHtzHoYtCjOnAjOpyU11b9rzi7Vzt_VLmEvK2AE7w-Jwj-14wU1cT94zhqh34m1fDH1FndlEy-eZCUkDVQLzyjckVN8EQBh_sLSVDLUKh1KBTc7YtSSfa8-reTe8ffKWAgWwFiye0wqGs_B8ev-0DWP0x7yOs</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Ning, Liang</creator><creator>Ishijima, Muneaki</creator><creator>Kaneko, Haruka</creator><creator>Kurihara, Hidetake</creator><creator>Arikawa-Hirasawa, Eri</creator><creator>Kubota, Mitsuaki</creator><creator>Liu, Lizu</creator><creator>Xu, Zhuo</creator><creator>Futami, Ippei</creator><creator>Yusup, Anwarjan</creator><creator>Miyahara, Katsumi</creator><creator>Xu, Shouyu</creator><creator>Kaneko, Kazuo</creator><creator>Kurosawa, Hisashi</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110601</creationdate><title>Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis</title><author>Ning, Liang ; Ishijima, Muneaki ; Kaneko, Haruka ; Kurihara, Hidetake ; Arikawa-Hirasawa, Eri ; Kubota, Mitsuaki ; Liu, Lizu ; Xu, Zhuo ; Futami, Ippei ; Yusup, Anwarjan ; Miyahara, Katsumi ; Xu, Shouyu ; Kaneko, Kazuo ; Kurosawa, Hisashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-ce825f3d189b107cf3d368c6d4c793e2d193198be2710d8393809dccdd6e5ecf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cartilage diseases</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-2</topic><topic>Degeneration</topic><topic>Female</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin-1beta - metabolism</topic><topic>Interstitial collagenase</topic><topic>Knee</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 1 - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menisci, Tibial - metabolism</topic><topic>Menisci, Tibial - pathology</topic><topic>Menisci, Tibial - physiopathology</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Orthopedics</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - metabolism</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Synovial Membrane - metabolism</topic><topic>Synovial Membrane - pathology</topic><topic>Synovial Membrane - physiopathology</topic><topic>Synovitis - metabolism</topic><topic>Synovitis - pathology</topic><topic>Synovitis - physiopathology</topic><topic>Synovium</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ning, Liang</creatorcontrib><creatorcontrib>Ishijima, Muneaki</creatorcontrib><creatorcontrib>Kaneko, Haruka</creatorcontrib><creatorcontrib>Kurihara, Hidetake</creatorcontrib><creatorcontrib>Arikawa-Hirasawa, Eri</creatorcontrib><creatorcontrib>Kubota, Mitsuaki</creatorcontrib><creatorcontrib>Liu, Lizu</creatorcontrib><creatorcontrib>Xu, Zhuo</creatorcontrib><creatorcontrib>Futami, Ippei</creatorcontrib><creatorcontrib>Yusup, Anwarjan</creatorcontrib><creatorcontrib>Miyahara, Katsumi</creatorcontrib><creatorcontrib>Xu, Shouyu</creatorcontrib><creatorcontrib>Kaneko, Kazuo</creatorcontrib><creatorcontrib>Kurosawa, Hisashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International orthopaedics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ning, Liang</au><au>Ishijima, Muneaki</au><au>Kaneko, Haruka</au><au>Kurihara, Hidetake</au><au>Arikawa-Hirasawa, Eri</au><au>Kubota, Mitsuaki</au><au>Liu, Lizu</au><au>Xu, Zhuo</au><au>Futami, Ippei</au><au>Yusup, Anwarjan</au><au>Miyahara, Katsumi</au><au>Xu, Shouyu</au><au>Kaneko, Kazuo</au><au>Kurosawa, Hisashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis</atitle><jtitle>International orthopaedics</jtitle><stitle>International Orthopaedics (SICOT)</stitle><addtitle>Int Orthop</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>35</volume><issue>6</issue><spage>831</spage><epage>838</epage><pages>831-838</pages><issn>0341-2695</issn><eissn>1432-5195</eissn><abstract>An enhanced expression of the inflammatory mediators in the perimeniscal synovium in knee osteoarthritis (OA) has been suggested to contribute to progressive cartilage degeneration. However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. Medial perimeniscal synovial samples were obtained from 23 patients with Kellgren-Lawrence (K/L) grades 2 to 4 of medial knee OA. Immunohistochemical analysis of the synovium revealed that the MMP-1, COX-2 and IL-1β expression of the patients with K/L 4 to be significantly reduced in comparison to those with either K/L 2 or 3, while the TGF-β expression showed the opposite. The synovial expression of MMP-1 and IL-1β showed a significant negative correlation with the severity of OA, while that of TGF-β again showed the opposite. In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1β expression in synovium decreased depending upon the severity of OA, while the TGF-β expression increased.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20517696</pmid><doi>10.1007/s00264-010-1045-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Cartilage diseases Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Degeneration Female Growth factors Humans Inflammation Inflammation Mediators - metabolism Interleukin-1beta - metabolism Interstitial collagenase Knee Male Matrix metalloproteinase Matrix Metalloproteinase 1 - metabolism Medicine Medicine & Public Health Menisci, Tibial - metabolism Menisci, Tibial - pathology Menisci, Tibial - physiopathology Middle Aged Original Paper Orthopedics Osteoarthritis Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Osteoarthritis, Knee - physiopathology Severity of Illness Index Synovial Membrane - metabolism Synovial Membrane - pathology Synovial Membrane - physiopathology Synovitis - metabolism Synovitis - pathology Synovitis - physiopathology Synovium Transforming Growth Factor beta - metabolism |
title | Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis |
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