Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis

► This review discusses a systemic regulatory network regulating metabolism and aging. ► SIRT1 functions as a key mediator controlling metabolic responses in various tissues. ► NAMPT functions as a pace maker regulating circadian NAD production and SIRT1. ► Their interplay defines specific tissues a...

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Bibliographic Details
Published in:FEBS letters 2011-06, Vol.585 (11), p.1657-1662
Main Author: Imai, Shin-ichiro
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Humans
Longevity
NAD - biosynthesis
NAD World
NAMPT
Nicotinamide Phosphoribosyltransferase - metabolism
SIRT1
Sirtuin 1 - metabolism
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Summary:► This review discusses a systemic regulatory network regulating metabolism and aging. ► SIRT1 functions as a key mediator controlling metabolic responses in various tissues. ► NAMPT functions as a pace maker regulating circadian NAD production and SIRT1. ► Their interplay defines specific tissues as critical frailty points in the NAD World. ► Frailty tissues determine the hierarchical regulatory dynamics of mammalian aging. Many countries are facing social and economic problems due to increased elderly demographics. With these demands, it is now critical to understand the fundamental regulatory mechanism for aging and longevity in mammals. Our studies on the mammalian NAD-dependent deacetylase SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT)-mediated systemic NAD biosynthesis led us to propose a comprehensive model for the systemic regulatory network connecting metabolism and aging, termed the “NAD World”. In this article, I will discuss the importance of SIRT1 and NAMPT-mediated NAD biosynthesis in the NAD World and the system dynamics of this hierarchical network for the connection between metabolism and aging.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2011.04.060