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Influenza Vaccine Given to Pregnant Women Reduces Hospitalization Due to Influenza in Their Infants
Background. Infants aged
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| Published in: | Clinical infectious diseases 2010-12, Vol.51 (12), p.1355-1361 |
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| container_end_page | 1361 |
| container_issue | 12 |
| container_start_page | 1355 |
| container_title | Clinical infectious diseases |
| container_volume | 51 |
| creator | Benowitz, Isaac Esposito, Daina B. Gracey, Kristina D. Shapiro, Eugene D. Vázquez, Marietta |
| description | Background. Infants aged |
| doi_str_mv | 10.1086/657309 |
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| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3106242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>29764739</jstor_id><oup_id>10.1086/657309</oup_id><sourcerecordid>29764739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-1df48201197ffb83a8f5c9bd49068d4144d1aa682f4dd94ccf71d4d95843263f3</originalsourceid><addsrcrecordid>eNp1kV1vFCEYhYnR2Fr1H2hGE_VqFIaPgRsTU7XbZKumqa3xhrB8tKyzsMJMo_31Mpl1V028grzn4XDgAPAQwZcIcvaK0RZDcQvsI4rbmlGBbpc9pLwmHPM9cC_nJYQIcUjvgr1mVATk-0AfB9cNNtyo6lxp7YOtjvy1DVUfq0_JXgYV-uoirsrk1JpB21zNYl77XnX-RvU-hurtYEd6Z-RDdXZlfRpH5Xi-D-441WX7YLMegM_v350dzur5x6PjwzfzWlPI-xoZR3hTMorWuQXHijuqxcIQARk3BBFikFKMN44YI4jWrkWGGEE5wQ3DDh-A15PvelisrNE29El1cp38SqWfMiov_1aCv5KX8VpiBFlDmmLwYmOQ4vfB5l6ufNa261SwcciSQ04YYQwV8uk_5DIOKZTXSY4YRyXTaPd8gnSKOSfrtlEQlGNrcmqtgI__DL7FftdUgGcbQGWtOpdU0D7vOFw-sBG4cE8mLg7r_1_2aGKWuY9p5yFaRlo86vWk-9zbH1tdpW-Stbilcvblqzw9v6An5GQuP-BfYRjB0g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>816815842</pqid></control><display><type>article</type><title>Influenza Vaccine Given to Pregnant Women Reduces Hospitalization Due to Influenza in Their Infants</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Oxford Journals Online</source><creator>Benowitz, Isaac ; Esposito, Daina B. ; Gracey, Kristina D. ; Shapiro, Eugene D. ; Vázquez, Marietta</creator><creatorcontrib>Benowitz, Isaac ; Esposito, Daina B. ; Gracey, Kristina D. ; Shapiro, Eugene D. ; Vázquez, Marietta</creatorcontrib><description>Background. Infants aged <12 months are at high risk of hospitalization for influenza. Influenza vaccine is recommended for pregnant women and for most children; however, no vaccine is approved for infants aged !6 months. Effective approaches are needed to protect this vulnerable population. Vaccination of women during pregnancy may protect the infant through transfer of antibodies from the mother. Few studies have examined the effectiveness of this strategy, and those studies produced mixed results. Methods. In a matched case-control study, case patients were infants aged <12 months admitted to a large urban hospital in the northeastern United States because of laboratory-confirmed influenza from 2000 to 2009. For each case, we enrolled 1 or 2 control subjects who were infants who tested negative for influenza and matched cases by date of birth and date of hospitalization (within 4 weeks). Vaccine effectiveness was calculated on the basis of matched odds ratios and was adjusted for confounding. Results. The mothers of 2 (2.2%) of 91 case subjects and 31 (19.9%) of 156 control subjects aged <6 months, and 1 (4.6%) of 22 case subjects and 2 (5.6%) of 36 control subjects aged ⩾6 months, had received influenza vaccine during pregnancy. The effectiveness of influenza vaccine given to mothers during pregnancy in preventing hospitalization among their infants, adjusted for potential confounders, was 91.5% (95% confidence interval [CI], 61.7%–98.1%; P = .001) for infants aged <6 months. The unadjusted effectiveness was 90.7% (95% CI, 59.9%–97.8%; P = .001). Conclusions. Influenza vaccine given to pregnant women is 91.5% effective in preventing hospitalization of their infants for influenza in the first 6 months of life.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/657309</identifier><identifier>PMID: 21058908</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Oxford: The University of Chicago Press</publisher><subject>and Commentaries ; Antibodies ; ARTICLES AND COMMENTARIES ; Babies ; Biological and medical sciences ; Case-Control Studies ; Chronic diseases ; Female ; Hospital admissions ; Hospitalization ; Hospitalization - statistics & numerical data ; Human viral diseases ; Humans ; Immunity, Maternally-Acquired ; Infant ; Infant, Newborn ; Infants ; Infections ; Infectious diseases ; Influenza ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Male ; Medical sciences ; Mothers ; New England ; Pregnancy ; Treatment Outcome ; Vaccination ; Vaccines ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Womens health</subject><ispartof>Clinical infectious diseases, 2010-12, Vol.51 (12), p.1355-1361</ispartof><rights>2010 The Infectious Diseases Society of America</rights><rights>2010 by the Infectious Diseases Society of America 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Dec 15, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-1df48201197ffb83a8f5c9bd49068d4144d1aa682f4dd94ccf71d4d95843263f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29764739$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29764739$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23508293$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21058908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benowitz, Isaac</creatorcontrib><creatorcontrib>Esposito, Daina B.</creatorcontrib><creatorcontrib>Gracey, Kristina D.</creatorcontrib><creatorcontrib>Shapiro, Eugene D.</creatorcontrib><creatorcontrib>Vázquez, Marietta</creatorcontrib><title>Influenza Vaccine Given to Pregnant Women Reduces Hospitalization Due to Influenza in Their Infants</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><addtitle>Clin Infect Dis</addtitle><description>Background. Infants aged <12 months are at high risk of hospitalization for influenza. Influenza vaccine is recommended for pregnant women and for most children; however, no vaccine is approved for infants aged !6 months. Effective approaches are needed to protect this vulnerable population. Vaccination of women during pregnancy may protect the infant through transfer of antibodies from the mother. Few studies have examined the effectiveness of this strategy, and those studies produced mixed results. Methods. In a matched case-control study, case patients were infants aged <12 months admitted to a large urban hospital in the northeastern United States because of laboratory-confirmed influenza from 2000 to 2009. For each case, we enrolled 1 or 2 control subjects who were infants who tested negative for influenza and matched cases by date of birth and date of hospitalization (within 4 weeks). Vaccine effectiveness was calculated on the basis of matched odds ratios and was adjusted for confounding. Results. The mothers of 2 (2.2%) of 91 case subjects and 31 (19.9%) of 156 control subjects aged <6 months, and 1 (4.6%) of 22 case subjects and 2 (5.6%) of 36 control subjects aged ⩾6 months, had received influenza vaccine during pregnancy. The effectiveness of influenza vaccine given to mothers during pregnancy in preventing hospitalization among their infants, adjusted for potential confounders, was 91.5% (95% confidence interval [CI], 61.7%–98.1%; P = .001) for infants aged <6 months. The unadjusted effectiveness was 90.7% (95% CI, 59.9%–97.8%; P = .001). Conclusions. Influenza vaccine given to pregnant women is 91.5% effective in preventing hospitalization of their infants for influenza in the first 6 months of life.</description><subject>and Commentaries</subject><subject>Antibodies</subject><subject>ARTICLES AND COMMENTARIES</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chronic diseases</subject><subject>Female</subject><subject>Hospital admissions</subject><subject>Hospitalization</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunity, Maternally-Acquired</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Influenza vaccines</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mothers</subject><subject>New England</subject><subject>Pregnancy</subject><subject>Treatment Outcome</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><subject>Womens health</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kV1vFCEYhYnR2Fr1H2hGE_VqFIaPgRsTU7XbZKumqa3xhrB8tKyzsMJMo_31Mpl1V028grzn4XDgAPAQwZcIcvaK0RZDcQvsI4rbmlGBbpc9pLwmHPM9cC_nJYQIcUjvgr1mVATk-0AfB9cNNtyo6lxp7YOtjvy1DVUfq0_JXgYV-uoirsrk1JpB21zNYl77XnX-RvU-hurtYEd6Z-RDdXZlfRpH5Xi-D-441WX7YLMegM_v350dzur5x6PjwzfzWlPI-xoZR3hTMorWuQXHijuqxcIQARk3BBFikFKMN44YI4jWrkWGGEE5wQ3DDh-A15PvelisrNE29El1cp38SqWfMiov_1aCv5KX8VpiBFlDmmLwYmOQ4vfB5l6ufNa261SwcciSQ04YYQwV8uk_5DIOKZTXSY4YRyXTaPd8gnSKOSfrtlEQlGNrcmqtgI__DL7FftdUgGcbQGWtOpdU0D7vOFw-sBG4cE8mLg7r_1_2aGKWuY9p5yFaRlo86vWk-9zbH1tdpW-Stbilcvblqzw9v6An5GQuP-BfYRjB0g</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Benowitz, Isaac</creator><creator>Esposito, Daina B.</creator><creator>Gracey, Kristina D.</creator><creator>Shapiro, Eugene D.</creator><creator>Vázquez, Marietta</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101215</creationdate><title>Influenza Vaccine Given to Pregnant Women Reduces Hospitalization Due to Influenza in Their Infants</title><author>Benowitz, Isaac ; Esposito, Daina B. ; Gracey, Kristina D. ; Shapiro, Eugene D. ; Vázquez, Marietta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-1df48201197ffb83a8f5c9bd49068d4144d1aa682f4dd94ccf71d4d95843263f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>and Commentaries</topic><topic>Antibodies</topic><topic>ARTICLES AND COMMENTARIES</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chronic diseases</topic><topic>Female</topic><topic>Hospital admissions</topic><topic>Hospitalization</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunity, Maternally-Acquired</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Influenza vaccines</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - immunology</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mothers</topic><topic>New England</topic><topic>Pregnancy</topic><topic>Treatment Outcome</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benowitz, Isaac</creatorcontrib><creatorcontrib>Esposito, Daina B.</creatorcontrib><creatorcontrib>Gracey, Kristina D.</creatorcontrib><creatorcontrib>Shapiro, Eugene D.</creatorcontrib><creatorcontrib>Vázquez, Marietta</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benowitz, Isaac</au><au>Esposito, Daina B.</au><au>Gracey, Kristina D.</au><au>Shapiro, Eugene D.</au><au>Vázquez, Marietta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influenza Vaccine Given to Pregnant Women Reduces Hospitalization Due to Influenza in Their Infants</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clin Infect Dis</stitle><addtitle>Clin Infect Dis</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>51</volume><issue>12</issue><spage>1355</spage><epage>1361</epage><pages>1355-1361</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Background. Infants aged <12 months are at high risk of hospitalization for influenza. Influenza vaccine is recommended for pregnant women and for most children; however, no vaccine is approved for infants aged !6 months. Effective approaches are needed to protect this vulnerable population. Vaccination of women during pregnancy may protect the infant through transfer of antibodies from the mother. Few studies have examined the effectiveness of this strategy, and those studies produced mixed results. Methods. In a matched case-control study, case patients were infants aged <12 months admitted to a large urban hospital in the northeastern United States because of laboratory-confirmed influenza from 2000 to 2009. For each case, we enrolled 1 or 2 control subjects who were infants who tested negative for influenza and matched cases by date of birth and date of hospitalization (within 4 weeks). Vaccine effectiveness was calculated on the basis of matched odds ratios and was adjusted for confounding. Results. The mothers of 2 (2.2%) of 91 case subjects and 31 (19.9%) of 156 control subjects aged <6 months, and 1 (4.6%) of 22 case subjects and 2 (5.6%) of 36 control subjects aged ⩾6 months, had received influenza vaccine during pregnancy. The effectiveness of influenza vaccine given to mothers during pregnancy in preventing hospitalization among their infants, adjusted for potential confounders, was 91.5% (95% confidence interval [CI], 61.7%–98.1%; P = .001) for infants aged <6 months. The unadjusted effectiveness was 90.7% (95% CI, 59.9%–97.8%; P = .001). Conclusions. Influenza vaccine given to pregnant women is 91.5% effective in preventing hospitalization of their infants for influenza in the first 6 months of life.</abstract><cop>Oxford</cop><pub>The University of Chicago Press</pub><pmid>21058908</pmid><doi>10.1086/657309</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | and Commentaries Antibodies ARTICLES AND COMMENTARIES Babies Biological and medical sciences Case-Control Studies Chronic diseases Female Hospital admissions Hospitalization Hospitalization - statistics & numerical data Human viral diseases Humans Immunity, Maternally-Acquired Infant Infant, Newborn Infants Infections Infectious diseases Influenza Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - epidemiology Influenza, Human - prevention & control Male Medical sciences Mothers New England Pregnancy Treatment Outcome Vaccination Vaccines Viral diseases Viral diseases of the respiratory system and ent viral diseases Womens health |
| title | Influenza Vaccine Given to Pregnant Women Reduces Hospitalization Due to Influenza in Their Infants |
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