Loading…

What is flux balance analysis?

Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.

Saved in:
Bibliographic Details
Published in:Nature biotechnology 2010-03, Vol.28 (3), p.245-248
Main Authors: Orth, Jeffrey D, Thiele, Ines, Palsson, Bernhard Ø
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c533t-b6bdf6a57efc6557067a95e05ec0292432c50dab3b5144034783a2cbd9c1768e3
cites cdi_FETCH-LOGICAL-c533t-b6bdf6a57efc6557067a95e05ec0292432c50dab3b5144034783a2cbd9c1768e3
container_end_page 248
container_issue 3
container_start_page 245
container_title Nature biotechnology
container_volume 28
creator Orth, Jeffrey D
Thiele, Ines
Palsson, Bernhard Ø
description Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.
doi_str_mv 10.1038/nbt.1614
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3108565</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>746013367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-b6bdf6a57efc6557067a95e05ec0292432c50dab3b5144034783a2cbd9c1768e3</originalsourceid><addsrcrecordid>eNqFkVtLAzEQhYMotlbBX1CKIOrD1lwn3RdFijco-KL4GLLZbLtlu1uTXbH_3pTW1suDeZnAfJyZMwehY4L7BLPBZZnUfQKE76A2ERwiAjHshj8eyAgTAS104P0UYwwcYB-1KKaE8hi3Ufd1oute7ntZ0Xz0El3o0tieLnWx8Lm_PkR7mS68PVrXDnq5u30ePkSjp_vH4c0oMoKxOkogSTPQQtrMgBASg9SxsFhYg2lMOaNG4FQnLBGEc8y4HDBNTZLGhkgYWNZBVyvdeZPMbGpsWTtdqLnLZ9otVKVz9bNT5hM1rt4VCx4FiCBwthZw1Vtjfa1muTe2CH5s1XglOWDCGMj_ScYIAQEkkCe_yGnVuHAar2h4DChdyp2vIOMq753NNksTrJbhqBCOWoYT0O53kxvwK40AnK4B7Y0uMhfCyP2Wo0KCoHHgLlacD61ybN12sT9DPwHRyKJm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222236227</pqid></control><display><type>article</type><title>What is flux balance analysis?</title><source>Nature</source><creator>Orth, Jeffrey D ; Thiele, Ines ; Palsson, Bernhard Ø</creator><creatorcontrib>Orth, Jeffrey D ; Thiele, Ines ; Palsson, Bernhard Ø</creatorcontrib><description>Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt.1614</identifier><identifier>PMID: 20212490</identifier><identifier>CODEN: NABIF9</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/114/2390 ; 631/443/319 ; 631/61 ; Agriculture ; Bioinformatics ; Biological and medical sciences ; Biomass ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Escherichia coli - metabolism ; Fundamental and applied biological sciences. Psychology ; General aspects ; Life Sciences ; Mathematical analysis ; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) ; Metabolic Networks and Pathways ; Metabolites ; Models, Biological ; Oxygen - metabolism ; Phenotype ; primer ; Systems Biology - methods</subject><ispartof>Nature biotechnology, 2010-03, Vol.28 (3), p.245-248</ispartof><rights>Springer Nature America, Inc. 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-b6bdf6a57efc6557067a95e05ec0292432c50dab3b5144034783a2cbd9c1768e3</citedby><cites>FETCH-LOGICAL-c533t-b6bdf6a57efc6557067a95e05ec0292432c50dab3b5144034783a2cbd9c1768e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=22576529$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20212490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orth, Jeffrey D</creatorcontrib><creatorcontrib>Thiele, Ines</creatorcontrib><creatorcontrib>Palsson, Bernhard Ø</creatorcontrib><title>What is flux balance analysis?</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.</description><subject>631/114/2390</subject><subject>631/443/319</subject><subject>631/61</subject><subject>Agriculture</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Biomass</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Escherichia coli - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Life Sciences</subject><subject>Mathematical analysis</subject><subject>Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)</subject><subject>Metabolic Networks and Pathways</subject><subject>Metabolites</subject><subject>Models, Biological</subject><subject>Oxygen - metabolism</subject><subject>Phenotype</subject><subject>primer</subject><subject>Systems Biology - methods</subject><issn>1087-0156</issn><issn>1546-1696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkVtLAzEQhYMotlbBX1CKIOrD1lwn3RdFijco-KL4GLLZbLtlu1uTXbH_3pTW1suDeZnAfJyZMwehY4L7BLPBZZnUfQKE76A2ERwiAjHshj8eyAgTAS104P0UYwwcYB-1KKaE8hi3Ufd1oute7ntZ0Xz0El3o0tieLnWx8Lm_PkR7mS68PVrXDnq5u30ePkSjp_vH4c0oMoKxOkogSTPQQtrMgBASg9SxsFhYg2lMOaNG4FQnLBGEc8y4HDBNTZLGhkgYWNZBVyvdeZPMbGpsWTtdqLnLZ9otVKVz9bNT5hM1rt4VCx4FiCBwthZw1Vtjfa1muTe2CH5s1XglOWDCGMj_ScYIAQEkkCe_yGnVuHAar2h4DChdyp2vIOMq753NNksTrJbhqBCOWoYT0O53kxvwK40AnK4B7Y0uMhfCyP2Wo0KCoHHgLlacD61ybN12sT9DPwHRyKJm</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Orth, Jeffrey D</creator><creator>Thiele, Ines</creator><creator>Palsson, Bernhard Ø</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>What is flux balance analysis?</title><author>Orth, Jeffrey D ; Thiele, Ines ; Palsson, Bernhard Ø</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-b6bdf6a57efc6557067a95e05ec0292432c50dab3b5144034783a2cbd9c1768e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/114/2390</topic><topic>631/443/319</topic><topic>631/61</topic><topic>Agriculture</topic><topic>Bioinformatics</topic><topic>Biological and medical sciences</topic><topic>Biomass</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering/Biotechnology</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Escherichia coli - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Life Sciences</topic><topic>Mathematical analysis</topic><topic>Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)</topic><topic>Metabolic Networks and Pathways</topic><topic>Metabolites</topic><topic>Models, Biological</topic><topic>Oxygen - metabolism</topic><topic>Phenotype</topic><topic>primer</topic><topic>Systems Biology - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orth, Jeffrey D</creatorcontrib><creatorcontrib>Thiele, Ines</creatorcontrib><creatorcontrib>Palsson, Bernhard Ø</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orth, Jeffrey D</au><au>Thiele, Ines</au><au>Palsson, Bernhard Ø</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>What is flux balance analysis?</atitle><jtitle>Nature biotechnology</jtitle><stitle>Nat Biotechnol</stitle><addtitle>Nat Biotechnol</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>28</volume><issue>3</issue><spage>245</spage><epage>248</epage><pages>245-248</pages><issn>1087-0156</issn><eissn>1546-1696</eissn><coden>NABIF9</coden><abstract>Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>20212490</pmid><doi>10.1038/nbt.1614</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1087-0156
ispartof Nature biotechnology, 2010-03, Vol.28 (3), p.245-248
issn 1087-0156
1546-1696
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3108565
source Nature
subjects 631/114/2390
631/443/319
631/61
Agriculture
Bioinformatics
Biological and medical sciences
Biomass
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Escherichia coli - metabolism
Fundamental and applied biological sciences. Psychology
General aspects
Life Sciences
Mathematical analysis
Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)
Metabolic Networks and Pathways
Metabolites
Models, Biological
Oxygen - metabolism
Phenotype
primer
Systems Biology - methods
title What is flux balance analysis?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T22%3A34%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=What%20is%20flux%20balance%20analysis?&rft.jtitle=Nature%20biotechnology&rft.au=Orth,%20Jeffrey%20D&rft.date=2010-03-01&rft.volume=28&rft.issue=3&rft.spage=245&rft.epage=248&rft.pages=245-248&rft.issn=1087-0156&rft.eissn=1546-1696&rft.coden=NABIF9&rft_id=info:doi/10.1038/nbt.1614&rft_dat=%3Cproquest_pubme%3E746013367%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c533t-b6bdf6a57efc6557067a95e05ec0292432c50dab3b5144034783a2cbd9c1768e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=222236227&rft_id=info:pmid/20212490&rfr_iscdi=true