Large, rare chromosomal deletions associated with severe early-onset obesity

Obesity is a highly heritable and genetically heterogeneous disorder. Here we investigated the contribution of copy number variation to obesity in 300 Caucasian patients with severe early-onset obesity, 143 of whom also had developmental delay. Large (>500 kilobases), rare (

Saved in:
Bibliographic Details
Published in:Nature (London) 2010-02, Vol.463 (7281), p.666-670
Main Authors: Hurles, Matthew E, Farooqi, I. Sadaf, Bochukova, Elena G, Huang, Ni, Keogh, Julia, Henning, Elana, Purmann, Carolin, Blaszczyk, Kasia, Saeed, Sadia, Hamilton-Shield, Julian, Clayton-Smith, Jill, O’Rahilly, Stephen
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Age of Onset
Autism
Biological and medical sciences
Child
Chromosome Deletion
Chromosomes, Human, Pair 16 - genetics
Cohort Studies
Control equipment
Delay
Deletion
Developmental Disabilities - complications
Developmental Disabilities - genetics
DNA Copy Number Variations - genetics
Genetic aspects
Genetic engineering
Genetics
Genome-Wide Association Study
Heterozygote
Humanities and Social Sciences
Humans
Hyperphagia - genetics
Inheritance Patterns - genetics
Insulin
Insulin resistance
Insulin Resistance - genetics
letter
Medical sciences
Mental illness
Metabolic diseases
multidisciplinary
Mutation - genetics
Obesity
Obesity - complications
Obesity - epidemiology
Obesity - genetics
Obesity - physiopathology
Patients
Reproduction
Science
Science (multidisciplinary)
Standard deviation
Studies
United Kingdom - epidemiology
White People
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obesity is a highly heritable and genetically heterogeneous disorder. Here we investigated the contribution of copy number variation to obesity in 300 Caucasian patients with severe early-onset obesity, 143 of whom also had developmental delay. Large (>500 kilobases), rare (
ISSN:0028-0836
1476-4687
1476-4687
DOI:10.1038/nature08689