Cingulate, Frontal, and Parietal Cortical Dysfunction in Attention-Deficit/Hyperactivity Disorder

Functional and structural neuroimaging have identified abnormalities of the brain that are likely to contribute to the neuropathophysiology of attention-deficit/hyperactivity disorder (ADHD). In particular, hypofunction of the brain regions comprising the cingulo-frontal-parietal cognitive-attention...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2011-06, Vol.69 (12), p.1160-1167
Main Author: Bush, George
Format: Article
Language:English
Subjects:
ADHD
attention
Attention - physiology
Attention Deficit Disorder with Hyperactivity - physiopathology
Brain Mapping - methods
cingulate
cognition
Cognition - physiology
decision
Decision Making - physiology
frontal
Frontal Lobe - physiopathology
Gyrus Cinguli - physiopathology
Humans
imaging
Models, Neurological
Neural Pathways - physiopathology
parietal
Parietal Lobe - physiopathology
Psychiatry
Reward
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Summary:Functional and structural neuroimaging have identified abnormalities of the brain that are likely to contribute to the neuropathophysiology of attention-deficit/hyperactivity disorder (ADHD). In particular, hypofunction of the brain regions comprising the cingulo-frontal-parietal cognitive-attention network have been consistently observed across studies. These are major components of neural systems that are relevant to ADHD, including cognitive/attention networks, motor systems, and reward/feedback-based processing systems. Moreover, these areas interact with other brain circuits that have been implicated in ADHD, such as the “default mode” resting state network. The ADHD imaging data related to cingulo-frontal-parietal network dysfunction will be selectively highlighted here to help facilitate its integration with the other information presented in this special issue. Together, these reviews will help shed light on the neurobiology of ADHD.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2011.01.022