Model systems to study plague pathogenesis and develop new therapeutics

The Gram negative bacterium Yersinia pestis can infect humans by multiple routes to cause plague. Three plague pandemics have occurred and Y. pestis has been linked to biowarfare in the past. The continued risk of plague as a bioweapon has prompted increased research to understand Y. pestis pathogen...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2010-01, Vol.1, p.119-119
Main Author: Lawrenz, Matthew B
Format: Article
Language:English
Subjects:
Animal Models
Microbiology
Plague pathogensis
plague vaccines
Yersinia pestis
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Summary:The Gram negative bacterium Yersinia pestis can infect humans by multiple routes to cause plague. Three plague pandemics have occurred and Y. pestis has been linked to biowarfare in the past. The continued risk of plague as a bioweapon has prompted increased research to understand Y. pestis pathogenesis and develop new plague therapeutics. Several in vivo models have been developed for this research and are reviewed here.
ISSN:1664-302X
1664-302X
2235-2988
DOI:10.3389/fmicb.2010.00119