MicroRNAs in platelet production and activation

MicroRNAs are small RNA molecules that modulate protein expression by degrading mRNA or repressing translation. They have been shown to play important roles in hematopoiesis, including embryonic stem cell differentiation, erythropoiesis, granulocytopoiesis/monocytopoiesis, lymphopoiesis, and megakar...

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Bibliographic Details
Published in:Blood 2011-05, Vol.117 (20), p.5289-5296
Main Authors: Edelstein, Leonard C., Bray, Paul F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Platelets - metabolism
Hematologic and hematopoietic diseases
Humans
Medical sciences
Megakaryocytes - metabolism
MicroRNAs - blood
MicroRNAs - genetics
Models, Biological
Platelet Activation - genetics
Platelets and Thrombopoiesis
Review
Thrombopoiesis - genetics
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Summary:MicroRNAs are small RNA molecules that modulate protein expression by degrading mRNA or repressing translation. They have been shown to play important roles in hematopoiesis, including embryonic stem cell differentiation, erythropoiesis, granulocytopoiesis/monocytopoiesis, lymphopoiesis, and megakaryocytopoiesis. miR-150 and miR-155 play divergent roles in megakaryocytopoiesis, with the former promoting development of megakaryocytes at the expense of erythrocytes and the latter causing a reduction in megakaryocyte colony formation. Platelets also contain fully functional miRNA machinery, and certain miRNA levels in platelets have been found to coordinate with reactivity to specific agonists and to pathologic states. This review will cover the current state of knowledge of miRNAs in megakaryocytes and platelets and the exciting possibilities for future research.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2011-01-292011