Antioxidant and Antinociceptive Effects of Citrus limon Essential Oil in Mice

The antioxidant and antinociceptive activities of Citrus limon essential oil (EO) were assessed in mice or in vitro tests. EO possesses a strong antioxidant potential according to the scavenging assays. Moreover, it presented scavenger activity against all in vitro tests. Orally, EO (50, 100, and 15...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2011-01, Vol.2011 (2011), p.1-8
Main Authors: Campêlo, Lidianne Mayra Lopes, de Almeida, Antonia Amanda Cardoso, de Freitas, Rizângela L. Mendes, Cerqueira, Gilberto Santos, de Sousa, Geane Felix, Saldanha, Gláucio Barros, Feitosa, Chistiane Mendes, de Freitas, Rivelilson Mendes
Format: Article
Language:English
Subjects:
Acids
Administration, Oral
Analgesics - analysis
Analgesics - antagonists & inhibitors
Animals
Antioxidants
Antioxidants - analysis
Antioxidants - pharmacology
Assaying
Biological and medical sciences
Biotechnology
Citrus - chemistry
Citrus limon
Disease Models, Animal
Essences and essential oils
Folk medicine
Free Radical Scavengers - analysis
Free Radical Scavengers - pharmacology
Free radicals
Health aspects
In vitro testing
Lemon
Lipids
Male
Medical sciences
Mice
Naloxone
Nociception
Oils, Volatile - administration & dosage
Oils, Volatile - isolation & purification
Pain - drug therapy
Pain Measurement
Pharmacology. Drug treatments
Physiological aspects
Plant Extracts - administration & dosage
Plant Extracts - analysis
Plant Extracts - isolation & purification
Plant Leaves - chemistry
Rutaceae
Scavengers
Scavenging
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The antioxidant and antinociceptive activities of Citrus limon essential oil (EO) were assessed in mice or in vitro tests. EO possesses a strong antioxidant potential according to the scavenging assays. Moreover, it presented scavenger activity against all in vitro tests. Orally, EO (50, 100, and 150 mg/kg) significantly reduced the number of writhes, and, at highest doses, it reduced the number of paw licks. Whereas naloxone antagonized the antinociceptive action of EO (highest doses), this suggested, at least, the participation of the opioid system. Further studies currently in progress will enable us to understand the action mechanisms of EO.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2011/678673