Near‐infrared fluorescence imaging of lymphatics in head and neck lymphedema

Background Lymphedema is a complication that may occur after surgical resection and radiation treatment in a number of cancer types and is especially debilitating in regions where treatment options are limited. Although upper and lower extremity lymphedema may be effectively treated with manual lymp...

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Bibliographic Details
Published in:Head & neck 2012-03, Vol.34 (3), p.448-453
Main Authors: Maus, Erik A., Tan, I‐Chih, Rasmussen, John C., Marshall, Milton V., Fife, Caroline E., Smith, Latisha A., Guilliod, Renie, Sevick‐Muraca, Eva M., Smith, Russell B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Compassionate Use Trials
Diseases of the lymphatic vessels
Drainage
fluorescence imaging
Fluorescent Dyes
Fluoroscopy
Humans
Indocyanine Green
lymphedema
Lymphedema - diagnosis
Lymphedema - etiology
Lymphedema - therapy
Male
manual lymph drainage
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
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Summary:Background Lymphedema is a complication that may occur after surgical resection and radiation treatment in a number of cancer types and is especially debilitating in regions where treatment options are limited. Although upper and lower extremity lymphedema may be effectively treated with manual lymphatic drainage (MLD) therapies and devices that use compression to direct proximal flow of lymph fluids, head and neck lymphedema is more challenging. Methods and Results Herein, we describe the compassionate use of an investigatory technique of near‐infrared (NIR) fluorescence imaging to understand the lymphatic anatomy and function, help direct MLD, and use 3‐dimensional (3D) surface profilometry to monitor response to therapy in a patient with head and neck lymphedema after surgery and radiation treatment. Conclusion NIR fluorescence imaging provides a mapping of functional lymph vessels for direction of efficient MLD therapy in the head and neck. Additional studies are needed to assess the efficacy of MLD therapy when directed by NIR fluorescence imaging. © 2010 Wiley Periodicals, Inc. Head Neck, 2012
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21538