Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer

• Published in: Annals of surgical oncology 2011-07, Vol.18 (7), p.1830-1836
• Main Authors: Kim, Hee Jeong, Lee, Yu Mi, Ko, Beon Seok, Lee, Jong Won, Yu, Jong Han, Son, Byung Ho, Gong, Gyung-Yub, Kim, Sung Bae, Ahn, Sei Hyun
• Format: Article
• Language: English
• Subjects: Bone Density Conservation Agents - therapeutic use; Breast Neoplasms - drug therapy; Breast Neoplasms - etiology; Breast Neoplasms - pathology; Breast Oncology; Female; Humans; Lymphatic Metastasis; Medicine; Medicine & Public Health; Middle Aged; Oncology; Prognosis; Prospective Studies; Receptor, ErbB-2 - metabolism; Receptors, Estrogen - metabolism; Receptors, Progesterone - metabolism; Retrospective Studies; Surgery; Surgical Oncology; Survival Rate; Vitamin D - therapeutic use; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-010-1465-6

Purpose Vitamin D deficiency may be an indicator of poor prognosis in patients with breast cancer before surgery. We investigated the association between serum vitamin D concentration and breast cancer prognosis according to intrinsic cancer subtypes. Methods From June to December 2006, serum 25-OHD was measured in 310 Korean women with breast cancer who were treated at the Asan Medical Center, Korea. Clinicopathologic data were examined to determine the prognostic effects of serum 25-OHD. Expression of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (Her2) were measured using tissue microarrays. Patients were classified with luminal A, luminal B, Her2-enriched, or basal-like subtypes of breast cancer. Results Mean patient age was 48.7 years, and mean serum 25-OHD concentration was 31.4 ± 16.1 ng/ml. The 25-OHD levels were deficient (