Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2011-04, Vol.3 (4), p.391-394
Main Authors: Moskalev, Alexey, Shaposhnikov, Mikhail
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Drosophila melanogaster - drug effects
Drosophila melanogaster - physiology
Female
Longevity - drug effects
Male
NF-kappa B - antagonists & inhibitors
Pyrrolidines - pharmacology
Research Paper
Thiocarbamates - pharmacology
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Summary:Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.100314