Entry and exit mechanisms at the cis-face of the Golgi complex

Vesicular transport of protein and lipid cargo from the endoplasmic reticulum (ER) to cis-Golgi compartments depends on coat protein complexes, Rab GTPases, tethering factors, and membrane fusion catalysts. ER-derived vesicles deliver cargo to an ER-Golgi intermediate compartment (ERGIC) that then f...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2011-07, Vol.3 (7), p.a005207-a005207
Main Authors: Lorente-Rodríguez, Andrés, Barlowe, Charles
Format: Article
Language:English
Subjects:
COP-Coated Vesicles - metabolism
COP-Coated Vesicles - physiology
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum - ultrastructure
Golgi Apparatus - metabolism
Golgi Apparatus - physiology
Golgi Apparatus - ultrastructure
Membrane Fusion
Membrane Fusion Proteins - physiology
Models, Biological
Protein Structure, Tertiary
Secretory Pathway
Vesicular Transport Proteins - chemistry
Vesicular Transport Proteins - physiology
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Summary:Vesicular transport of protein and lipid cargo from the endoplasmic reticulum (ER) to cis-Golgi compartments depends on coat protein complexes, Rab GTPases, tethering factors, and membrane fusion catalysts. ER-derived vesicles deliver cargo to an ER-Golgi intermediate compartment (ERGIC) that then fuses with and/or matures into cis-Golgi compartments. The forward transport pathway to cis-Golgi compartments is balanced by a retrograde directed pathway that recycles transport machinery back to the ER. How trafficking through the ERGIC and cis-Golgi is coordinated to maintain organelle structure and function is poorly understood and highlights central questions regarding trafficking routes and organization of the early secretory pathway.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a005207