Entry and exit mechanisms at the cis-face of the Golgi complex

• Published in: Cold Spring Harbor perspectives in biology 2011-07, Vol.3 (7), p.a005207-a005207
• Main Authors: Lorente-Rodríguez, Andrés, Barlowe, Charles
• Format: Article
• Language: English
• Subjects: COP-Coated Vesicles - metabolism; COP-Coated Vesicles - physiology; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum - ultrastructure; Golgi Apparatus - metabolism; Golgi Apparatus - physiology; Golgi Apparatus - ultrastructure; Membrane Fusion; Membrane Fusion Proteins - physiology; Models, Biological; Protein Structure, Tertiary; Secretory Pathway; Vesicular Transport Proteins - chemistry; Vesicular Transport Proteins - physiology
• ISSN: 1943-0264; 1943-0264
• DOI: 10.1101/cshperspect.a005207

Vesicular transport of protein and lipid cargo from the endoplasmic reticulum (ER) to cis-Golgi compartments depends on coat protein complexes, Rab GTPases, tethering factors, and membrane fusion catalysts. ER-derived vesicles deliver cargo to an ER-Golgi intermediate compartment (ERGIC) that then fuses with and/or matures into cis-Golgi compartments. The forward transport pathway to cis-Golgi compartments is balanced by a retrograde directed pathway that recycles transport machinery back to the ER. How trafficking through the ERGIC and cis-Golgi is coordinated to maintain organelle structure and function is poorly understood and highlights central questions regarding trafficking routes and organization of the early secretory pathway.