A protein which specifically binds to single stranded TTAGGGn repeats

Nuclei from tissues of many vertebrates contain a soluble 37 kd protein which binds with a high degree of specificity to oligonucleotides which contain the G rich strand of the telomertc terminal repeats, TTAGGG. In some tissues this Is an abundant nuclear protein.

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Bibliographic Details
Published in:Nucleic acids research 1992-03, Vol.20 (6), p.1387-1391
Main Authors: McKay, Stewart J., Cooke, Howard
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Base Sequence
Binding and carrier proteins
Biological and medical sciences
DNA, Single-Stranded - metabolism
DNA-Binding Proteins - isolation & purification
DNA-Binding Proteins - metabolism
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
Mice
Molecular Sequence Data
Proteins
Repetitive Sequences, Nucleic Acid
Species Specificity
Telomere - metabolism
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Description
Summary:Nuclei from tissues of many vertebrates contain a soluble 37 kd protein which binds with a high degree of specificity to oligonucleotides which contain the G rich strand of the telomertc terminal repeats, TTAGGG. In some tissues this Is an abundant nuclear protein.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/20.6.1387