Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings

Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables indep...

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Bibliographic Details
Published in:Nano letters 2011-02, Vol.11 (2), p.808-813
Main Authors: Enlow, Elizabeth M, Luft, J. Christopher, Napier, Mary E, DeSimone, Joseph M
Format: Article
Language:English
Subjects:
Absorption
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Chemical synthesis methods
Cross-disciplinary physics: materials science
rheology
Crystallization - methods
Diffusion
Drug Compounding - methods
Exact sciences and technology
Lactic Acid - chemistry
Materials science
Methods of nanofabrication
Nanocapsules - chemistry
Nanocapsules - ultrastructure
Nanocrystalline materials
Nanoscale materials and structures: fabrication and characterization
Particle Size
Physics
Polyglycolic Acid - chemistry
Taxoids - administration & dosage
Taxoids - chemistry
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Summary:Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl104117p