Green tea and bone health: Evidence from laboratory studies

Osteoporosis is a major health problem in the elderly. Epidemiological evidence has shown an association between tea consumption and the prevention of bone loss in the elderly population. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this popul...

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Bibliographic Details
Published in:Pharmacological research 2011-08, Vol.64 (2), p.155-161
Main Authors: Shen, Chwan-Li, Yeh, James K., Cao, Jay J., Chyu, Ming-Chien, Wang, Jia-Sheng
Format: Article
Language:English
Subjects:
Aging
Animals
Antioxidant
at-risk population
biochemical mechanisms
Bone and Bones
Bone and Bones - drug effects
bone density
Bone Density - drug effects
bone formation
bone fractures
Bone loss
Bone mass
Bone mineral density
bone resorption
Cell
cell culture
disease prevention
drug effects
elderly
Etiology
Fractures
Geriatrics
green tea
Human
Humans
Inflammation
ingestion
men
Obesity
osteoblasts
osteoclasts
Osteoporosis
Osteoporosis, Postmenopausal
Osteoporosis, Postmenopausal - prevention & control
Osteoporotic Fractures
Osteoporotic Fractures - prevention & control
oxidative stress
Post-menopause
prevention & control
protective effect
Rat
risk
Risk assessment
Sex hormones
Supplementation
Tea
Tea polyphenols
women
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Summary:Osteoporosis is a major health problem in the elderly. Epidemiological evidence has shown an association between tea consumption and the prevention of bone loss in the elderly population. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures. This review describes the effect of green tea with its bioactive components on bone health with an emphasis on the following: (i) the etiology of osteoporosis, (ii) evidence of osteo-protective impacts of green tea on bone mass and microarchitecture in various bone loss models in which induced by aging, sex hormone deficiency, and chronic inflammation, (iii) discussion of impacts of green tea on bone mass in two obesity models, (iv) observation of short-term green tea supplementation given to postmenopausal women with low bone mass, (v) possible mechanisms for the osteo-protective effects of green tea bioactive compounds, and (vi) a summary and future research direction of green tea and bone health.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2011.03.012