Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels

A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, r...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2011-03, Vol.23 (12), p.H79-H83
Main Authors: Rhee, Minsoung, Valencia, Pedro M., Rodriguez, Maria I., Langer, Robert, Farokhzad, Omid C., Karnik, Rohit
Format: Article
Language:English
Subjects:
3D hydrodynamic focusing
Hydrodynamics
microfluidic
Microtechnology - instrumentation
Microtechnology - methods
Nanoparticles - chemistry
nanoprecipitation
PLGA-PEG
polymeric nanoparticles
Polymers - chemical synthesis
Polymers - chemistry
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Summary:A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201004333