Chlamydia trachomatis Vaccine Research through the Years

Chlamydia trachomatis is a Gram-negative obligate intracellular bacterium. It is the leading cause of bacterial sexual transmitted infections (STIs). World Health Organization figures estimated that over 90 million new cases of genital C. trachomatis infections occur worldwide each year. A vaccinati...

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Bibliographic Details
Published in:Infectious Diseases in Obstetrics and Gynecology 2011, Vol.2011 (2011), p.387-395
Main Authors: Schautteet, Katelijn, De Clercq, Evelien, Vanrompay, Daisy
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial vaccines
Biomedical Research
Chlamydia
Chlamydia infections
Chlamydia Infections - immunology
Chlamydia Infections - prevention & control
Chlamydia trachomatis
Chlamydia trachomatis - immunology
Complications and side effects
Deoxyribonucleic acid
Development and progression
Diagnosis
DNA
Health aspects
History, 20th Century
History, 21st Century
Humans
Infections
Infertility
Mathematical models
Mens health
Mice
Natural history
Pathology
Prevention
Public health
Review
Rickettsial Vaccines
Sexually transmitted diseases
Statistics
STD
Vaccines
Vaccines, Synthetic
Womens health
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Summary:Chlamydia trachomatis is a Gram-negative obligate intracellular bacterium. It is the leading cause of bacterial sexual transmitted infections (STIs). World Health Organization figures estimated that over 90 million new cases of genital C. trachomatis infections occur worldwide each year. A vaccination program is considered to be the best approach to reduce the prevalence of C. trachomatis infections, as it would be much cheaper and have a greater impact on controlling C. trachomatis infections worldwide rather than a screening program or treating infections with antibiotics. Currently, there are no vaccines available which effectively protect against a C. trachomatis genital infection despite the many efforts that have been made throughout the years. In this paper, the many attempts to develop a protective vaccine against a genital C. trachomatis infection will be reviewed.
ISSN:1064-7449
1098-0997
DOI:10.1155/2011/963513