Effects of weight loss on serum vitamin D in postmenopausal women12345

• Published in: The American journal of clinical nutrition 2011-07, Vol.94 (1), p.95-103
• Main Authors: Mason, Caitlin, Xiao, Liren, Imayama, Ikuyo, Duggan, Catherine R, Bain, Carolyn, Foster-Schubert, Karen E, Kong, Angela, Campbell, Kristin L, Wang, Ching-Yun, Neuhouser, Marian L, Li, Li, W Jeffery, Robert, Robien, Kim, Alfano, Catherine M, Blackburn, George L, McTiernan, Anne
• Format: Article
• Language: English
• Subjects: Nutritional Status, Dietary Intake, and Body Composition
• ISSN: 0002-9165; 1938-3207
• DOI: 10.3945/ajcn.111.015552

Background: Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese. Objective: The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations. Design: Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87). The diet intervention was a group-based reduced-calorie program with a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous intensity aerobic activity daily for 5 d/wk. Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo. Results: No significant change in serum 25(OH)D was found between the intervention and control groups. Women who lost