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Getting Closer to the Dirty Little Secret

The molecular mechanism behind alum adjuvanticity is probably the oldest secret of immunology. In this issue of Immunity, Kuroda et al. (2011) and Kool et al. (2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell response induced by aluminum salts.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2011-04, Vol.34 (4), p.455-458
Main Authors: Pelka, Karin, Latz, Eicke
Format: Article
Language:English
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Summary:The molecular mechanism behind alum adjuvanticity is probably the oldest secret of immunology. In this issue of Immunity, Kuroda et al. (2011) and Kool et al. (2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell response induced by aluminum salts.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2011.04.003