Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma

Diffuse brainstem glioma has a poor prognosis, and there are few long-term survivors. We looked for clinical, conventional magnetic resonance (MR), and MR spectroscopic (MRS) findings predictive of the prognosis of patients with brainstem glioma. Our institutional review board approved this retrospe...

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Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2011-07, Vol.13 (7), p.791-801
Main Authors: Yamasaki, Fumiyuki, Kurisu, Kaoru, Kajiwara, Yoshinori, Watanabe, Yosuke, Takayasu, Takeshi, Akiyama, Yuji, Saito, Taiichi, Hanaya, Ryosuke, Sugiyama, Kazuhiko
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain Stem Neoplasms - diagnosis
Brain Stem Neoplasms - metabolism
Brain Stem Neoplasms - mortality
Child
Child, Preschool
Clinical Investigations
Female
Humans
Lactic Acid - metabolism
Magnetic Resonance Spectroscopy
Male
Middle Aged
Pons
Prognosis
Retrospective Studies
Survival Rate
Young Adult
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Summary:Diffuse brainstem glioma has a poor prognosis, and there are few long-term survivors. We looked for clinical, conventional magnetic resonance (MR), and MR spectroscopic (MRS) findings predictive of the prognosis of patients with brainstem glioma. Our institutional review board approved this retrospective study of 23 patients with diffuse intrinsic pontine or diffuse medullary brainstem glioma treated during the period 2000-2009. To evaluate prognostic values, we performed a Kaplan-Meier survival analysis (log-rank test) that incorporated the patients' age and sex, symptom duration, the presence or absence of cranial nerve palsy, long tract sign, ataxia, and cysts, the chemotherapeutic regimen, Gd enhancement, longitudinal and cerebellar extension, basilar artery encasement, and MRS parameters. Of the 23 diffuse brainstem gliomas, 19 were located at the pons (ratio of male to female patients, 1.1:1). The mean age of the 23 patients was 15.9 years (range, 4-50 years); 16 were aged
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/nor038