Optical coherence tomography for the quantitative study of cerebrovascular physiology

Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. More...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2011-06, Vol.31 (6), p.1339-1345
Main Authors: Srinivasan, Vivek J, Atochin, Dmitriy N, Radhakrishnan, Harsha, Jiang, James Y, Ruvinskaya, Svetlana, Wu, Weicheng, Barry, Scott, Cable, Alex E, Ayata, Cenk, Huang, Paul L, Boas, David A
Format: Article
Language:English
Subjects:
Angiography - methods
Animals
Biological and medical sciences
Cerebral Cortex - blood supply
Cerebrovascular Circulation
Investigative techniques, diagnostic techniques (general aspects)
Laser-Doppler Flowmetry - methods
Medical sciences
Nervous system
Neurology
Radionuclide investigations
Rats
Rats, Sprague-Dawley
Tomography, Optical Coherence - methods
Vascular diseases and vascular malformations of the nervous system
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Summary:Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.2011.19