Optofluidic phantom mimicking optical properties of porcine livers

One strategy for assessing efficacy of a liver transplant is to monitor perfusion and oxygenation after transplantation. An implantable optical sensor is being developed to overcome inadequacies of current monitoring approaches. To facilitate sensor design while minimizing animal use, a polydimethyl...

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Bibliographic Details
Published in:Biomedical optics express 2011-07, Vol.2 (7), p.1877-1892
Main Authors: Long, Ruiqi, King, Travis, Akl, Tony, Ericson, M Nance, Wilson, Mark, Coté, Gerard L, McShane, Michael J
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
ANIMALS
APPROXIMATIONS
BASIC BIOLOGICAL SCIENCES
Calibration, Validation and Phantom Studies
DESIGN
ELASTOMERS
IMPLANTS
LIVER
MONITORING
MONITORS
OPTICAL PROPERTIES
PERFUSED TISSUES
PHANTOMS
SENSORS
TRANSPLANTS
WAVELENGTHS
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Summary:One strategy for assessing efficacy of a liver transplant is to monitor perfusion and oxygenation after transplantation. An implantable optical sensor is being developed to overcome inadequacies of current monitoring approaches. To facilitate sensor design while minimizing animal use, a polydimethylsiloxane (PDMS)-based liver phantom was developed to mimic the optical properties of porcine liver in the 630-1000 nm wavelength range and the anatomical geometry of liver parenchyma. Using soft lithography to construct microfluidic channels in pigmented elastomer enabled the 2D approximation of hexagonal liver lobules with 15mm sinusoidal channels, which will allow perfusion with blood-mimicking fluids to facilitate the development of the liver perfusion and oxygenation monitoring system.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.2.001877