Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma?

To investigate the association of glutathione S-transferase (GST) GSTM1, GSTT1, and GSTP1 genes with the risk of primary open angle glaucoma (POAG) and clinical features of the disease. We conducted a case-control study that included 87 Brazilian patients with POAG and 85 healthy controls matched fo...

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Bibliographic Details
Published in:Molecular vision 2011, Vol.17, p.1679-1686
Main Authors: Rocha, Auta Viviane, Talbot, Teddy, Magalhães da Silva, Thiago, Almeida, Maria Clarinda, Menezes, Carlos Alberto, Di Pietro, Giuliano, Rios-Santos, Fabrício
Format: Article
Language:English
Subjects:
Aged
Brazil
Case-Control Studies
Female
Gene Deletion
Gene Dosage
Genetic Predisposition to Disease
Genotype
Glaucoma, Open-Angle - genetics
Glaucoma, Open-Angle - pathology
Glutathione S-Transferase pi - genetics
Glutathione S-Transferase pi - metabolism
Glutathione Transferase - deficiency
Glutathione Transferase - genetics
Glutathione Transferase - metabolism
Humans
Intraocular Pressure
Male
Middle Aged
Optic Nerve - metabolism
Optic Nerve - pathology
Polymerase Chain Reaction - methods
Polymorphism, Genetic
Risk Factors
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Summary:To investigate the association of glutathione S-transferase (GST) GSTM1, GSTT1, and GSTP1 genes with the risk of primary open angle glaucoma (POAG) and clinical features of the disease. We conducted a case-control study that included 87 Brazilian patients with POAG and 85 healthy controls matched for age, ethnicity, and sex, whose blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction (PCR) based methods. The GSTM1 null polymorphism was significantly more common in the POAG than in the controls group (OR: 2.1, 95% CI: 1.13-3.9; p=0.018). The combined GSTM1 null/GSTT1+ genotype and GSTM1 null/GSTP1 Ile/Val or Val/Val was more prevalent in POAG patients, being a risk factor for POAG (OR: 2.4, 95% CI: 1.16-4.9; p=0.016 and OR: 2.7, 95% CI: 1.07-6.74; p=0.033, respectively). The GSTM1 null/GSTT1+ genotype were associated with higher levels of IOP of both eyes and with more severe defect of the right eye optic nerve. The GSTM1 null/GSTP1 Ile/Val or Val/Val genotypes were associated with higher levels of IOP and more advanced defect of the right eye optic nerve and visual field. We demonstrate that GSTM1 null polymorphism is associated with POAG in the Brazilian population.
ISSN:1090-0535
1090-0535