Heritability of neurocognitive traits in familial schizophrenia

Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian fa...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2009-09, Vol.150B (6), p.845-853
Main Authors: Husted, Janice A., Lim, Sooyeol, Chow, Eva W.C., Greenwood, Celia, Bassett, Anne S.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
chromosome 1q23
Chromosomes, Human, Pair 1 - genetics
Classical genetics, quantitative genetics, hybrids
Cognition
Cognition Disorders - genetics
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
genetics
Genetics of eukaryotes. Biological and molecular evolution
heritability
Human
Humans
Male
Medical genetics
Medical sciences
Memory
Middle Aged
Neuropsychological Tests
processing speed
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance
Psychopathology. Psychiatry
Psychoses
Quantitative Trait, Heritable
Schizophrenia
Schizophrenia - complications
Schizophrenia - genetics
visuospatial
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Summary:Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian families with familial schizophrenia linked to 1q23 who had neurocognitive testing results available. Heritability of 13 standard measures assessing motor skills, processing speed, verbal, and visuospatial memory, attention/working memory, executive functioning, and IQ was estimated using variance component models and SOLAR software. We then investigated bivariate relationships between those variables found to be heritable. IQ showed the highest heritability (h2 = 0.64–0.74) and seven other neurocognitive measures, reflecting immediate and delayed verbal memory, attention/working memory, delayed visual memory, processing speed and motor skills, showed significant heritability (h2 = 0.31–0.62) under one or more of the models assessed. A schizophrenia diagnostic covariate was significant (P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30907