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Heritability of neurocognitive traits in familial schizophrenia
Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian fa...
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| Published in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2009-09, Vol.150B (6), p.845-853 |
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| container_end_page | 853 |
| container_issue | 6 |
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| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
| container_volume | 150B |
| creator | Husted, Janice A. Lim, Sooyeol Chow, Eva W.C. Greenwood, Celia Bassett, Anne S. |
| description | Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian families with familial schizophrenia linked to 1q23 who had neurocognitive testing results available. Heritability of 13 standard measures assessing motor skills, processing speed, verbal, and visuospatial memory, attention/working memory, executive functioning, and IQ was estimated using variance component models and SOLAR software. We then investigated bivariate relationships between those variables found to be heritable. IQ showed the highest heritability (h2 = 0.64–0.74) and seven other neurocognitive measures, reflecting immediate and delayed verbal memory, attention/working memory, delayed visual memory, processing speed and motor skills, showed significant heritability (h2 = 0.31–0.62) under one or more of the models assessed. A schizophrenia diagnostic covariate was significant (P |
| doi_str_mv | 10.1002/ajmg.b.30907 |
| format | article |
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Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian families with familial schizophrenia linked to 1q23 who had neurocognitive testing results available. Heritability of 13 standard measures assessing motor skills, processing speed, verbal, and visuospatial memory, attention/working memory, executive functioning, and IQ was estimated using variance component models and SOLAR software. We then investigated bivariate relationships between those variables found to be heritable. IQ showed the highest heritability (h2 = 0.64–0.74) and seven other neurocognitive measures, reflecting immediate and delayed verbal memory, attention/working memory, delayed visual memory, processing speed and motor skills, showed significant heritability (h2 = 0.31–0.62) under one or more of the models assessed. A schizophrenia diagnostic covariate was significant (P < 0.0001) for all heritable variables. Bivariate analyses suggested that memory‐IQ and visuomotor‐processing speed formed two groups of heritable traits. The results provide further evidence of the heritability of selected neurocognitive measures, and their relationship to schizophrenia and underlying genetic architecture. Composite measures of memory or processing speed may be heritable phenotypes useful for studies of neurocognition. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.30907</identifier><identifier>PMID: 19180565</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; chromosome 1q23 ; Chromosomes, Human, Pair 1 - genetics ; Classical genetics, quantitative genetics, hybrids ; Cognition ; Cognition Disorders - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; genetics ; Genetics of eukaryotes. Biological and molecular evolution ; heritability ; Human ; Humans ; Male ; Medical genetics ; Medical sciences ; Memory ; Middle Aged ; Neuropsychological Tests ; processing speed ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance ; Psychopathology. Psychiatry ; Psychoses ; Quantitative Trait, Heritable ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - genetics ; visuospatial</subject><ispartof>American journal of medical genetics. 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Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian families with familial schizophrenia linked to 1q23 who had neurocognitive testing results available. Heritability of 13 standard measures assessing motor skills, processing speed, verbal, and visuospatial memory, attention/working memory, executive functioning, and IQ was estimated using variance component models and SOLAR software. We then investigated bivariate relationships between those variables found to be heritable. IQ showed the highest heritability (h2 = 0.64–0.74) and seven other neurocognitive measures, reflecting immediate and delayed verbal memory, attention/working memory, delayed visual memory, processing speed and motor skills, showed significant heritability (h2 = 0.31–0.62) under one or more of the models assessed. A schizophrenia diagnostic covariate was significant (P < 0.0001) for all heritable variables. Bivariate analyses suggested that memory‐IQ and visuomotor‐processing speed formed two groups of heritable traits. The results provide further evidence of the heritability of selected neurocognitive measures, and their relationship to schizophrenia and underlying genetic architecture. Composite measures of memory or processing speed may be heritable phenotypes useful for studies of neurocognition. © 2009 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>chromosome 1q23</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cognition</subject><subject>Cognition Disorders - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>heritability</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>processing speed</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Quantitative Trait, Heritable</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - genetics</subject><subject>visuospatial</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp90c1v0zAYB-AIgdgH3DijXGAXUl7HcWxfQGNi3VAHCIHgZr3-SOuRxMVOB91fT7aWApedbMnP-2H9suwJgQkBKF_iZTef6AkFCfxetk8YK4tKsG_3d_eK7GUHKV0CUGCcP8z2iCQCWM32s9dnLvoBtW_9sM5Dk_duFYMJ894P_srlQ0Q_pNz3eYPdiLDNk1n467BcRNd7fJQ9aLBN7vH2PMy-nL79fHJWzD5Mz0-OZ4VhsuSFBlJLARYclGg4lUAsRWuF00ZqS6gp0VaWGk1RNk5qYRhwoXkJKK2t6WH2atN3udKds8b142atWkbfYVyrgF79_9L7hZqHK0UJBc7F2OBo2yCGHyuXBtX5ZFzbYu_CKilOKyCU12yUz--UJQgy7sVH-GIDTQwpRdfs1iGgbrJRN9korW6zGfnTf7_wF2_DGMGzLcBksG0i9sannSuJoKwUcnR043761q3vHKqO311M_4wvNlU-De7Xrgrjd1Vzypn6-n6qPl2wavZxStQb-hvy77kM</recordid><startdate>20090905</startdate><enddate>20090905</enddate><creator>Husted, Janice A.</creator><creator>Lim, Sooyeol</creator><creator>Chow, Eva W.C.</creator><creator>Greenwood, Celia</creator><creator>Bassett, Anne S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090905</creationdate><title>Heritability of neurocognitive traits in familial schizophrenia</title><author>Husted, Janice A. ; Lim, Sooyeol ; Chow, Eva W.C. ; Greenwood, Celia ; Bassett, Anne S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5927-b016980d0e02ac73901d3add8ebc9bd13c2ad4d3cb3a9fe9b8c5078b720a9dd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>chromosome 1q23</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Cognition</topic><topic>Cognition Disorders - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>heritability</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>processing speed</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Quantitative Trait, Heritable</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - genetics</topic><topic>visuospatial</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Husted, Janice A.</creatorcontrib><creatorcontrib>Lim, Sooyeol</creatorcontrib><creatorcontrib>Chow, Eva W.C.</creatorcontrib><creatorcontrib>Greenwood, Celia</creatorcontrib><creatorcontrib>Bassett, Anne S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Husted, Janice A.</au><au>Lim, Sooyeol</au><au>Chow, Eva W.C.</au><au>Greenwood, Celia</au><au>Bassett, Anne S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heritability of neurocognitive traits in familial schizophrenia</atitle><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2009-09-05</date><risdate>2009</risdate><volume>150B</volume><issue>6</issue><spage>845</spage><epage>853</epage><pages>845-853</pages><issn>1552-4841</issn><eissn>1552-485X</eissn><abstract>Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. 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Bivariate analyses suggested that memory‐IQ and visuomotor‐processing speed formed two groups of heritable traits. The results provide further evidence of the heritability of selected neurocognitive measures, and their relationship to schizophrenia and underlying genetic architecture. Composite measures of memory or processing speed may be heritable phenotypes useful for studies of neurocognition. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19180565</pmid><doi>10.1002/ajmg.b.30907</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of medical genetics. Part B, Neuropsychiatric genetics, 2009-09, Vol.150B (6), p.845-853 |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences chromosome 1q23 Chromosomes, Human, Pair 1 - genetics Classical genetics, quantitative genetics, hybrids Cognition Cognition Disorders - genetics Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease genetics Genetics of eukaryotes. Biological and molecular evolution heritability Human Humans Male Medical genetics Medical sciences Memory Middle Aged Neuropsychological Tests processing speed Psychology. Psychoanalysis. Psychiatry Psychomotor Performance Psychopathology. Psychiatry Psychoses Quantitative Trait, Heritable Schizophrenia Schizophrenia - complications Schizophrenia - genetics visuospatial |
| title | Heritability of neurocognitive traits in familial schizophrenia |
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