Isolated Hepatitis B Core Antibody Is Associated with HIV and Ongoing but Not Resolved Hepatitis C Virus Infection in a Cohort of US Women

To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)—infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable h...

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Bibliographic Details
Published in:The Journal of infectious diseases 2007-05, Vol.195 (10), p.1437-1442
Main Authors: French, Audrey L, Operskalski, Eva, Peters, Marion, Strickler, Howard D, Tien, Phyllis C, Sharp, Gerald B, Glesby, Marshall J, Young, Mary, Augenbraun, Michael, Seaberg, Eric, Kovacs, Andrea
Format: Article
Language:English
Subjects:
Adult
Antibodies
Biological and medical sciences
Cohort Studies
Female
Fundamental and applied biological sciences. Psychology
Grants
Hepacivirus
Hepacivirus - isolation & purification
Hepatitis antigens
Hepatitis B
Hepatitis B Antibodies - blood
Hepatitis B Core Antigens - analysis
Hepatitis B Core Antigens - immunology
Hepatitis B virus
Hepatitis C - complications
Hepatitis C - epidemiology
Hepatitis C virus
HIV
HIV Infections - complications
HIV Infections - epidemiology
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Prevalence
Prospective Studies
RNA
United States - epidemiology
Viral diseases
Viral hepatitis
Viral Load
Viremia
Virology
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Summary:To characterize predictors of isolated hepatitis B core antibody (anti-HBc) among human immunodeficiency virus (HIV)—infected and HIV-uninfected women, we compared 702 women with anti-HBc and hepatitis B surface antibody (anti-HBs) with 490 women with isolated anti-HBc (1.8% of whom had detectable hepatitis B virus [HBV] DNA). Factors independently associated with isolated anti-HBc without viremia were detectable hepatitis C virus (HCV) RNA, HIV positivity, history of injection drug use, >10 lifetime sex partners, and HIV RNA level >100,000 copies/mL. Anti-HBs levels were lower among anti-HCV—positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability.
ISSN:0022-1899
1537-6613
DOI:10.1086/515578