Recent Advances in p53 Research and Cancer Treatment

TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to...

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Bibliographic Details
Published in:BioMed research international 2011-01, Vol.2011 (2011), p.1-7
Main Authors: Suzuki, Kazufumi, Matsubara, Hisahiro
Format: Article
Language:English
Subjects:
Apoptosis - genetics
Cancer
Care and treatment
Cell Cycle - genetics
DNA Damage
Gene Expression Regulation, Neoplastic
Genes, p53 - genetics
Genetic Therapy
Health aspects
Humans
Immunotherapy
Mutation - genetics
Neoplasms - genetics
Neoplasms - therapy
Oncology, Experimental
Physiological aspects
Proteins
Review
Tumor suppressor genes
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Protein p53 - physiology
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Summary:TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to cellular stress. We herein review the recent advances in p53 research and focus on apoptosis, cell cycle arrest, and senescence in response to stress. We also review the clinical applications of p53-based therapy for human cancer.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2011/978312